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CRYSTAL STRUCTURE OF ESCHELICHIA COLI BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE

Source organism: Escherichia coli
Biochemical function: L-isoleucine-2-oxoglutarate transaminase activity
Biological process: carboxylic acid biosynthetic process
Cellular component: cytosol

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EC 2.6.1.42: Branched-chain-amino-acid transaminase

Reaction catalysed:
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate
Systematic name:
Branched-chain-amino-acid:2-oxoglutarate aminotransferase
Alternative Name(s):
  • Branched-chain amino acid aminotransferase
  • Branched-chain amino acid--glutamate transaminase
  • Branched-chain aminotransferase
  • Glutamate--branched-chain amino acid transaminase
  • L-branched chain amino acid aminotransferase
  • Transaminase B

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01063
Domain description: Amino-transferase class IV
Occurring in:
  1. Branched-chain-amino-acid aminotransferase
The deposited structure of PDB entry 1iye contains 3 copies of Pfam domain PF01063 (Amino-transferase class IV) in Branched-chain-amino-acid aminotransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR018300
Domain description: Aminotransferase, class IV, conserved site
Occurring in:
  1. Branched-chain-amino-acid aminotransferase
IPR043132
Domain description: Branched-chain-amino-acid aminotransferase-like, C-terminal
Occurring in:
  1. Branched-chain-amino-acid aminotransferase
IPR001544
Domain description: Aminotransferase class IV
Occurring in:
  1. Branched-chain-amino-acid aminotransferase
IPR033939
Domain description: Branched-chain aminotransferase
Occurring in:
  1. Branched-chain-amino-acid aminotransferase
IPR043131
Domain description: Branched-chain-amino-acid aminotransferase-like, N-terminal
Occurring in:
  1. Branched-chain-amino-acid aminotransferase
IPR005785
Domain description: Branched-chain amino acid aminotransferase I
Occurring in:
  1. Branched-chain-amino-acid aminotransferase
IPR036038
Domain description: Aminotransferase-like, PLP-dependent enzymes
Occurring in:
  1. Branched-chain-amino-acid aminotransferase

Structure domains

CATH CATH domains
3.30.470.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: D-amino Acid Aminotransferase; Chain A, domain 1
Homology: D-amino Acid Aminotransferase; Chain A, domain 1
Occurring in:
  1. Branched-chain-amino-acid aminotransferase
The deposited structure of PDB entry 1iye contains 3 copies of CATH domain 3.30.470.10 (D-amino Acid Aminotransferase; Chain A, domain 1) in Branched-chain-amino-acid aminotransferase. Showing 1 copy in chain A.
3.20.10.10
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: D-amino Acid Aminotransferase; Chain A, domain 2
Homology: D-amino Acid Aminotransferase, subunit A, domain 2
Occurring in:
  1. Branched-chain-amino-acid aminotransferase
The deposited structure of PDB entry 1iye contains 3 copies of CATH domain 3.20.10.10 (D-amino Acid Aminotransferase; Chain A, domain 2) in Branched-chain-amino-acid aminotransferase. Showing 1 copy in chain A.
SCOP SCOP annotation
56753
Class: Multi-domain proteins (alpha and beta)
Fold: D-aminoacid aminotransferase-like PLP-dependent enzymes
Superfamily: D-aminoacid aminotransferase-like PLP-dependent enzymes
Occurring in:
  1. Branched-chain-amino-acid aminotransferase
The deposited structure of PDB entry 1iye contains 3 copies of SCOP domain 56753 (D-aminoacid aminotransferase-like PLP-dependent enzymes) in Branched-chain-amino-acid aminotransferase. Showing 1 copy in chain A.

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