› 1jb6

X-ray diffraction
1.7Å resolution

Crystal Structure of Dimerization Domain (1-33) of HNF-1alpha

Released:
DOI: 10.2210/pdb1jb6/pdb
PDB entry 1jb6 coloured by chain, front view.
PDB entry 1jb6 coloured by chain, side view.
PDB entry 1jb6 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The dimerization domain of HNF-1alpha: structure and plasticity of an intertwined four-helix bundle with application to diabetes mellitus.
Narayana N, Hua Q, Weiss MA
J Mol Biol 310 635-58 (2001)
PMID: 11439029

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
homo octamer
Assembly name:
PDBe Complex ID:
PDB-CPX-149604 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatocyte nuclear factor 1-alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 33 amino acids
Theoretical weight: 3.62 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P22361 (Residues: 1-33; Coverage: 5%)
Gene names: Hnf-1, Hnf-1a, Hnf1a, Tcf1

Ligands and Environments

No bound ligands
2 modified residues:
Ligand NLE 2 x NLE
Ligand MSE 2 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21212
Unit cell:
a: 28.42Å b: 42.19Å c: 42.43Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.231 0.245
Expression system: Not provided

Quick links

Citations

2 review citations

A Review of Functional Characterization of Single Amino Acid Change Mutations in HNF Transcription Factors in MODY Pathogenesis.
Çubuk et al. (2021)
1 more

1 mention without citation

Conformations of islet amyloid polypeptide monomers in a membrane environment: implications for fibril formation.
Duan et al. (2012)