› 1jks

X-ray diffraction
1.5Å resolution

1.5A X-RAY STRUCTURE OF APO FORM OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE

Released:
DOI: 10.2210/pdb1jks/pdb
PDB entry 1jks coloured by chain, front view.
PDB entry 1jks coloured by chain, side view.
PDB entry 1jks coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression.
Tereshko V, Teplova M, Brunzelle J, Watterson DM, Egli M
Nat Struct Biol 8 899-907 (2001)
PMID: 11573098

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156788 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Death-associated protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 294 amino acids
Theoretical weight: 33.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P53355 (Residues: 2-295; Coverage: 21%)
Gene names: DAPK, DAPK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 5ID-B
Spacegroup: P212121
Unit cell:
a: 46.93Å b: 62.55Å c: 88.56Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.183 0.202
Expression system: Escherichia coli

Quick links

Citations

25 review citations

Regulation of protein kinases; controlling activity through activation segment conformation.
Nolen et al. (2004)
24 more

9 mentions without citation

Substrate and docking interactions in serine/threonine protein kinases.
Goldsmith et al. (2007)
8 more