› 1jmj

X-ray diffraction
2.35Å resolution

Crystal Structure of Native Heparin Cofactor II

Released:
DOI: 10.2210/pdb1jmj/pdb
PDB entry 1jmj coloured by chain, front view.
PDB entry 1jmj coloured by chain, side view.
PDB entry 1jmj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism.
Baglin TP, Carrell RW, Church FC, Esmon CT, Huntington JA
Proc Natl Acad Sci U S A 99 11079-84 (2002)
PMID: 12169660

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138707 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Heparin cofactor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 480 amino acids
Theoretical weight: 55.03 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P05546 (Residues: 20-499; Coverage: 100%)
Gene names: HCF2, SERPIND1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
2 bound ligands:
Ligand CA 1 x CA
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.1
Spacegroup: P21
Unit cell:
a: 74.73Å b: 80Å c: 92.24Å
α: 90° β: 102.04° γ: 90°
R-values:
R R work R free
0.208 0.208 0.255

Quick links

Citations

39 review citations

The interactions between inflammation and coagulation.
Esmon CT. (2005)
38 more

12 mentions without citation

The Inhibition of Serine Proteases by Serpins Is Augmented by Negatively Charged Heparin: A Concise Review of Some Clinically Relevant Interactions.
Chan et al. (2024)
11 more