› 1jwm

X-ray diffraction
2.7Å resolution

Crystal Structure of the Complex of the MHC Class II Molecule HLA-DR1(HA peptide 306-318) with the Superantigen SEC3

Released:
DOI: 10.2210/pdb1jwm/pdb
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Source organisms:
Primary publication:
Structural, energetic, and functional analysis of a protein-protein interface at distinct stages of affinity maturation.
Sundberg EJ, Andersen PS, Schlievert PM, Karjalainen K, Mariuzza RA
Structure 11 1151-61 (2003)
PMID: 12962633

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-135329 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
HLA class II histocompatibility antigen, DR alpha chain Chain: A
Molecule details ›
Chain: A
Length: 182 amino acids
Theoretical weight: 21.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01903 (Residues: 26-207; Coverage: 80%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DRB1 beta chain Chain: B
Molecule details ›
Chain: B
Length: 190 amino acids
Theoretical weight: 22.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01911 (Residues: 30-219; Coverage: 80%)
Gene name: HLA-DRB1
Sequence domains:
Structure domains:
HA peptide Chain: C
Enterotoxin type C-3 Chain: D

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 19-ID
Spacegroup: R3
Unit cell:
a: 171.695Å b: 171.695Å c: 120.796Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.192 0.192 0.228
Expression system: Escherichia coli

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Citations

1 review citation

Soluble T cell receptor Vβ domains engineered for high-affinity binding to staphylococcal or streptococcal superantigens.
Sharma et al. (2014)
14 other articles

11 mentions without citation

Conformational variation in structures of classical and non-classical MHCII proteins and functional implications.
Painter et al. (2012)
10 more

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