› 1k6r

X-ray diffraction
2.3Å resolution

STRUCTURE OF THE CLASS D BETA-LACTAMASE OXA-10 IN COMPLEX WITH MOXALACTAM

Released:
DOI: 10.2210/pdb1k6r/pdb
PDB entry 1k6r coloured by chain, front view.
PDB entry 1k6r coloured by chain, side view.
PDB entry 1k6r coloured by chain, top view.
Source organism: Pseudomonas aeruginosa
Entry authors: Kerff F, Fonze E, Sauvage E, Frere JM, Charlier P

Function and Biology Details

Reaction catalysed: 
A beta-lactam + H(2)O = a substituted beta-amino acid
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146960 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-lactamase OXA-10 Chains: A, B
Molecule details ›
Chains: A, B
Length: 248 amino acids
Theoretical weight: 27.71 KDa
Source organism: Pseudomonas aeruginosa
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P14489 (Residues: 20-266; Coverage: 100%)
Gene names: OXA-10, bla, oxa10, pse2
Sequence domains: Penicillin binding protein transpeptidase domain
Structure domains: DD-peptidase/beta-lactamase superfamily

Ligands and Environments

1 bound ligand:
Ligand MX1 2 x MX1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 48.706Å b: 96.003Å c: 125.195Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.198 0.237
Expression system: Escherichia coli BL21(DE3)

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