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ALPHA1-ANTITRYPSIN

Source organism: Homo sapiens
Biochemical function: identical protein binding
Biological process: negative regulation of peptidase activity
Cellular component: ficolin-1-rich granule lumen

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GO terms

Sequence family

Pfam Protein family (Pfam)
PF00079
Domain description: Serpin (serine protease inhibitor)
Occurring in:
  1. Alpha-1-antitrypsin
The deposited structure of PDB entry 1kct contains 1 copy of Pfam domain PF00079 (Serpin (serine protease inhibitor)) in Alpha-1-antitrypsin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR023796
Domain description: Serpin domain
Occurring in:
  1. Alpha-1-antitrypsin
IPR023795
Domain description: Serpin, conserved site
Occurring in:
  1. Alpha-1-antitrypsin
IPR042185
Domain description: Serpin superfamily, domain 2
Occurring in:
  1. Alpha-1-antitrypsin
IPR042178
Domain description: Serpin superfamily, domain 1
Occurring in:
  1. Alpha-1-antitrypsin
IPR000215
Domain description: Serpin family
Occurring in:
  1. Alpha-1-antitrypsin
IPR036186
Domain description: Serpin superfamily
Occurring in:
  1. Alpha-1-antitrypsin

Structure domains

CATH CATH domains
2.30.39.10
Class: Mainly Beta
Architecture: Roll
Topology: Alpha-1-antitrypsin; domain 1
Homology: Alpha-1-antitrypsin, domain 1
Occurring in:
  1. Alpha-1-antitrypsin
The deposited structure of PDB entry 1kct contains 1 copy of CATH domain 2.30.39.10 (Alpha-1-antitrypsin; domain 1) in Alpha-1-antitrypsin. Showing 1 copy in chain A.
3.30.497.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Antithrombin; Chain I, domain 2
Homology: Antithrombin, subunit I, domain 2
Occurring in:
  1. Alpha-1-antitrypsin
The deposited structure of PDB entry 1kct contains 1 copy of CATH domain 3.30.497.10 (Antithrombin; Chain I, domain 2) in Alpha-1-antitrypsin. Showing 1 copy in chain A.
SCOP SCOP annotation
56575
Class: Multi-domain proteins (alpha and beta)
Fold: Serpins
Superfamily: Serpins
Occurring in:
  1. Alpha-1-antitrypsin
The deposited structure of PDB entry 1kct contains 1 copy of SCOP domain 56575 (Serpins) in Alpha-1-antitrypsin. Showing 1 copy in chain A.

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