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The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance.

Kjer-Nielsen L, Clements CS, Brooks AG, Purcell AW, McCluskey J, Rossjohn J
Structure 10 1521-32 (2002)
Cited: 62 times
EuropePMC logo PMID: 12429093

Abstract

Despite a potential repertoire of >10(15) alphabeta T cell receptors (TcR), the HLA B8-restricted cytolytic T cell response to a latent antigen of Epstein-Barr virus (EBV) is strikingly limited in the TcR sequences that are selected. Even in unrelated individuals this response is dominated by a single highly restricted TcR clonotype that selects identical combinations of hypervariable Valpha, Vbeta, D, J, and N region genes. We have determined the 1.5 A crystal structure of this "public" TcR, revealing that five of the six hypervariable loops adopt novel conformations providing a unique combining site that contains a deep pocket predicted to overlay the HLA B8-peptide complex. The findings suggest a structural basis for the immunodominance of this clonotype in the immune response to EBV.

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Reviews citing this publication (12)

  1. How TCRs bind MHCs, peptides, and coreceptors. Rudolph MG, Stanfield RL, Wilson IA. Annu Rev Immunol 24 419-466 (2006)
  2. T cell antigen receptor recognition of antigen-presenting molecules. Rossjohn J, Gras S, Miles JJ, Turner SJ, Godfrey DI, McCluskey J. Annu Rev Immunol 33 169-200 (2015)
  3. Deconstructing the form and function of the TCR/CD3 complex. Kuhns MS, Davis MM, Garcia KC. Immunity 24 133-139 (2006)
  4. The fidelity, occasional promiscuity, and versatility of T cell receptor recognition. Godfrey DI, Rossjohn J, McCluskey J. Immunity 28 304-314 (2008)
  5. Cross-reactivity of T cells and its role in the immune system. Petrova G, Ferrante A, Gorski J. Crit Rev Immunol 32 349-372 (2012)
  6. A structural voyage toward an understanding of the MHC-I-restricted immune response: lessons learned and much to be learned. Gras S, Burrows SR, Turner SJ, Sewell AK, McCluskey J, Rossjohn J. Immunol Rev 250 61-81 (2012)
  7. The structural bases of direct T-cell allorecognition: implications for T-cell-mediated transplant rejection. Gras S, Kjer-Nielsen L, Chen Z, Rossjohn J, McCluskey J. Immunol Cell Biol 89 388-395 (2011)
  8. Not just any T cell receptor will do. Bankovich AJ, Garcia KC. Immunity 18 7-11 (2003)
  9. Specificity on a knife-edge: the alphabeta T cell receptor. Clements CS, Dunstone MA, Macdonald WA, McCluskey J, Rossjohn J. Curr Opin Struct Biol 16 787-795 (2006)
  10. TCR-MHC docking orientation: natural selection, or thymic selection? Collins EJ, Riddle DS. Immunol Res 41 267-294 (2008)
  11. Antigen specificity of semi-invariant CD1d-restricted T cell receptors: the best of both worlds? Gumperz JE. Immunol Cell Biol 82 285-294 (2004)
  12. A T cell receptor goes public. Adams EJ, Garcia KC. Structure 10 1468-1469 (2002)

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