› 1kif

X-ray diffraction
2.6Å resolution

D-AMINO ACID OXIDASE FROM PIG KIDNEY

Released:
DOI: 10.2210/pdb1kif/pdb
PDB entry 1kif coloured by chain, front view.
PDB entry 1kif coloured by chain, side view.
PDB entry 1kif coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
Crystal structure of D-amino acid oxidase: a case of active site mirror-image convergent evolution with flavocytochrome b2.
Mattevi A, Vanoni MA, Todone F, Rizzi M, Teplyakov A, Coda A, Bolognesi M, Curti B
Proc Natl Acad Sci U S A 93 7496-501 (1996)
PMID: 8755502

Function and Biology Details

Reaction catalysed: 
A D-amino acid + H(2)O + O(2) = a 2-oxo carboxylate + NH(3) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-132445 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
D-amino-acid oxidase Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 347 amino acids
Theoretical weight: 39.38 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P00371 (Residues: 1-347; Coverage: 100%)
Gene name: DAO
Sequence domains: FAD dependent oxidoreductase
Structure domains:

Ligands and Environments


Cofactor: Ligand FAD 8 x FAD
1 bound ligand:
Ligand BEZ 8 x BEZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X31
Spacegroup: C2221
Unit cell:
a: 326.48Å b: 138.1Å c: 200.85Å
α: 90° β: 90° γ: 90°

Quick links

Citations

19 review citations

Evolution of protein function, from a structural perspective.
Todd et al. (1999)
18 more

5 mentions without citation

Oxidation of amines by flavoproteins.
Fitzpatrick PF. (2010)
4 more