› 1kvi

Solution NMR

Solution Structure of the Reduced Form of the First Heavy Metal Binding Motif of the Menkes Protein

Released:
DOI: 10.2210/pdb1kvi/pdb
PDB entry 1kvi coloured by chain, ensemble of 10 models, front view.
PDB entry 1kvi coloured by chain, ensemble of 10 models, side view.
PDB entry 1kvi coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structures of the reduced and Cu(I) bound forms of the first metal binding sequence of ATP7A associated with Menkes disease.
DeSilva TM, Veglia G, Opella SJ
Proteins 61 1038-49 (2005)
PMID: 16211579

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Cu(+)(Side 1) = ADP + phosphate + Cu(+)(Side 2)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170052 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Copper-transporting ATPase 1 Chain: A
Molecule details ›
Chain: A
Length: 79 amino acids
Theoretical weight: 8.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q04656 (Residues: 1-79; Coverage: 5%)
Gene names: ATP7A, MC1, MNK
Sequence domains: Heavy-metal-associated domain
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

Function and regulation of human copper-transporting ATPases.
Lutsenko et al. (2007)
8 more

2 mentions without citation

Structural biology of copper trafficking.
Boal et al. (2009)
1 more