› 1l8w

X-ray diffraction
2.3Å resolution

Crystal Structure of Lyme Disease Variable Surface Antigen VlsE of Borrelia burgdorferi

Released:
DOI: 10.2210/pdb1l8w/pdb
PDB entry 1l8w coloured by chain, front view.
PDB entry 1l8w coloured by chain, side view.
PDB entry 1l8w coloured by chain, top view.
Source organism: Borreliella burgdorferi
Primary publication:
Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi.
Eicken C, Sharma V, Klabunde T, Lawrenz MB, Hardham JM, Norris SJ, Sacchettini JC
J Biol Chem 277 21691-6 (2002)
PMID: 11923306

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-126542 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Variable large protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 348 amino acids
Theoretical weight: 35.27 KDa
Source organism: Borreliella burgdorferi
Expression system: Escherichia coli
UniProt:
  • Canonical: O06878 (Residues: 21-356; Coverage: 94%)
Gene name: vlsE
Sequence domains: Borrelia lipoprotein

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 8 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-D
Spacegroup: P2
Unit cell:
a: 85.171Å b: 59.178Å c: 116.149Å
α: 90° β: 104.58° γ: 90°
R-values:
R R work R free
0.216 0.216 0.291
Expression system: Escherichia coli

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Citations

19 review citations

AI-2-mediated signalling in bacteria.
Pereira et al. (2013)
18 more

24 mentions without citation

Changing of the guard: How the Lyme disease spirochete subverts the host immune response.
Chaconas et al. (2020)
23 more