› 1l9a

X-ray diffraction
2.9Å resolution

CRYSTAL STRUCTURE OF SRP19 IN COMPLEX WITH THE S DOMAIN OF SIGNAL RECOGNITION PARTICLE RNA

Released:
DOI: 10.2210/pdb1l9a/pdb
PDB entry 1l9a coloured by chain, front view.
PDB entry 1l9a coloured by chain, side view.
PDB entry 1l9a coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of SRP19 in complex with the S domain of SRP RNA and its implication for the assembly of the signal recognition particle.
Oubridge C, Kuglstatter A, Jovine L, Nagai K
Mol Cell 9 1251-61 (2002)
PMID: 12086622

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176620 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Signal recognition particle 19 kDa protein Chain: A
Molecule details ›
Chain: A
Length: 87 amino acids
Theoretical weight: 10.34 KDa
Source organism: Methanocaldococcus jannaschii
Expression system: Escherichia coli
UniProt:
  • Canonical: Q58440 (Residues: 1-87; Coverage: 100%)
Gene names: MJ1034, srp19
Sequence domains: SRP19 protein
Structure domains: Signal recognition particle, SRP19-like subunit
signal recognition particle RNA S domain Chain: B
Molecule details ›
Chain: B
Length: 128 nucleotides
Theoretical weight: 41.57 KDa
Source organism: Homo sapiens
Expression system: Not provided
Sequence domains: Metazoan signal recognition particle RNA

Ligands and Environments

2 bound ligands:
Ligand MG 24 x MG
Ligand MMC 1 x MMC
1 modified residue:
Ligand CCC 1 x CCC

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P21212
Unit cell:
a: 70.765Å b: 223.875Å c: 43.024Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.264 0.264 0.296
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

15 review citations

Signal recognition particle: an essential protein-targeting machine.
Akopian et al. (2013)
14 more

9 mentions without citation

Structure, function and evolution of the signal recognition particle.
Nagai et al. (2003)
8 more