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FEZ-1-Y228A, A Mutant of the Metallo-beta-lactamase from Legionella gormanii

Source organism: Fluoribacter gormanii
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 3.5.2.6: Beta-lactamase

Reaction catalysed:
A beta-lactam + H(2)O = a substituted beta-amino acid
Systematic name:
Beta-lactam hydrolase
Alternative Name(s):
  • Ampicillinase
  • Beta-lactamase A, B, C
  • Beta-lactamase AME I
  • Beta-lactamase I-III
  • Cephalosporin-beta-lactamase
  • Cephalosporinase
  • Exopenicillinase
  • Neutrapen
  • Penicillin amido-beta-lactamhydrolase
  • Penicillin beta-lactamase
  • Penicillinase
  • Penicillinase I, II

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00753
Domain description: Metallo-beta-lactamase superfamily
Occurring in:
  1. Metallo-beta-lactamase domain-containing protein
The deposited structure of PDB entry 1l9y contains 2 copies of Pfam domain PF00753 (Metallo-beta-lactamase superfamily) in Metallo-beta-lactamase domain-containing protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001279
Domain description: Metallo-beta-lactamase
Occurring in:
  1. Metallo-beta-lactamase domain-containing protein
IPR036866
Domain description: Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Occurring in:
  1. Metallo-beta-lactamase domain-containing protein

Structure domain

CATH CATH domain
3.60.15.10
Class: Alpha Beta
Architecture: 4-Layer Sandwich
Topology: Metallo-beta-lactamase; Chain A
Homology: Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Occurring in:
  1. Metallo-beta-lactamase domain-containing protein
The deposited structure of PDB entry 1l9y contains 2 copies of CATH domain 3.60.15.10 (Metallo-beta-lactamase; Chain A) in Metallo-beta-lactamase domain-containing protein. Showing 1 copy in chain A.
SCOP SCOP annotation
56282
Class: Alpha and beta proteins (a+b)
Fold: Metallo-hydrolase/oxidoreductase
Superfamily: Metallo-hydrolase/oxidoreductase
Occurring in:
  1. Metallo-beta-lactamase domain-containing protein
The deposited structure of PDB entry 1l9y contains 2 copies of SCOP domain 56282 (Zn metallo-beta-lactamase) in Metallo-beta-lactamase domain-containing protein. Showing 1 copy in chain A.

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