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CRYSTAL STRUCTURE OF THE ACTIVE RAS PROTEIN COMPLEXED WITH THE RAS-INTERACTING DOMAIN OF RALGDS

Source organisms:
Biochemical function: GTP binding
Biological process: signal transduction
Cellular component: membrane

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EC 3.6.5.2: Small monomeric GTPase

Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Systematic name:
GTP phosphohydrolase (cell-regulating)

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00071
Domain description: Ras family
Occurring in:
  1. GTPase HRas, N-terminally processed
The deposited structure of PDB entry 1lfd contains 2 copies of Pfam domain PF00071 (Ras family) in GTPase HRas, N-terminally processed. Showing 1 copy in chain B.

PF00788
Domain description: Ras association (RalGDS/AF-6) domain
Occurring in:
  1. Ral guanine nucleotide dissociation stimulator
The deposited structure of PDB entry 1lfd contains 2 copies of Pfam domain PF00788 (Ras association (RalGDS/AF-6) domain) in Ral guanine nucleotide dissociation stimulator. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001806
Domain description: Small GTPase
Occurring in:
  1. GTPase HRas, N-terminally processed
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. GTPase HRas, N-terminally processed
IPR000159
Domain description: Ras-associating domain
Occurring in:
  1. Ral guanine nucleotide dissociation stimulator
IPR020849
Domain description: Small GTPase, Ras-type
Occurring in:
  1. GTPase HRas, N-terminally processed
IPR005225
Domain description: Small GTP-binding domain
Occurring in:
  1. GTPase HRas, N-terminally processed
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Ral guanine nucleotide dissociation stimulator
IPR015758
Domain description: Ral guanine nucleotide dissociation stimulator, RA domain
Occurring in:
  1. Ral guanine nucleotide dissociation stimulator

Structure domains

CATH CATH domains
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. GTPase HRas, N-terminally processed
The deposited structure of PDB entry 1lfd contains 2 copies of CATH domain 3.40.50.300 (Rossmann fold) in GTPase HRas, N-terminally processed. Showing 1 copy in chain B.
3.10.20.90
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Occurring in:
  1. Ral guanine nucleotide dissociation stimulator
The deposited structure of PDB entry 1lfd contains 2 copies of CATH domain 3.10.20.90 (Ubiquitin-like (UB roll)) in Ral guanine nucleotide dissociation stimulator. Showing 1 copy in chain A.
SCOP SCOP annotations
52592
Class: Alpha and beta proteins (a/b)
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Occurring in:
  1. GTPase HRas, N-terminally processed
The deposited structure of PDB entry 1lfd contains 2 copies of SCOP domain 52592 (G proteins) in GTPase HRas, N-terminally processed. Showing 1 copy in chain B.
54263
Class: Alpha and beta proteins (a+b)
Fold: beta-Grasp (ubiquitin-like)
Superfamily: Ubiquitin-like
Occurring in:
  1. Ral guanine nucleotide dissociation stimulator
The deposited structure of PDB entry 1lfd contains 2 copies of SCOP domain 54263 (Ras-binding domain, RBD) in Ral guanine nucleotide dissociation stimulator. Showing 1 copy in chain A.

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