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The crystal structure and biological function of leukemia inhibitory factor: implications for receptor binding.

Robinson RC, Grey LM, Staunton D, Vankelecom H, Vernallis AB, Moreau JF, Stuart DI, Heath JK, Jones EY
Cell 77 1101-16 (1994)
Cited: 123 times
EuropePMC logo PMID: 8020098

Abstract

The structure of murine leukemia inhibitory factor (LIF) has been determined by X-ray crystallography at 2.0 A resolution. The main chain fold conforms to the four alpha-helix bundle topology previously observed for several members of the hematopoietic cytokine family. Of these, LIF shows closest structural homology to granulocyte colony-stimulating factor and growth hormone (GH). Sequence alignments for the functionally related molecules oncostatin M and ciliary neurotrophic factor, when mapped to the LIF structure, indicate regions of conserved surface character. Analysis of the biological function and receptor specificity of a series of human-mouse LIF chimeras implicate two regions of receptor interaction that are located in the fourth helix and the preceding loop. A model for receptor binding based on the structure of the GH ligand-receptor complex requires additional, novel features to account for these data.

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Reviews citing this publication (23)

  1. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Heinrich PC, Behrmann I, Müller-Newen G, Schaper F, Graeve L. Biochem J 334 ( Pt 2) 297-314 (1998)
  2. Regulation of signal transduction and signal diversity by receptor oligomerization. Lemmon MA, Schlessinger J. Trends Biochem Sci 19 459-463 (1994)
  3. Leukemia inhibitory factor (LIF). Nicola NA, Babon JJ. Cytokine Growth Factor Rev 26 533-544 (2015)
  4. Interleukin-6: structure-function relationships. Simpson RJ, Hammacher A, Smith DK, Matthews JM, Ward LD. Protein Sci 6 929-955 (1997)
  5. Leukemia inhibitory factor, Interleukin 6, and other cytokines using the GP130 transducing receptor: roles in inflammation and injury. Gadient RA, Patterson PH. Stem Cells 17 127-137 (1999)
  6. Alpha and beta interferons and their receptor and their friends and relations. Uzé G, Lutfalla G, Mogensen KE. J Interferon Cytokine Res 15 3-26 (1995)
  7. Receptor recognition by gp130 cytokines. Bravo J, Heath JK. EMBO J 19 2399-2411 (2000)
  8. Emerging themes in structural biology of neurotrophic factors. Ibáñez CF. Trends Neurosci 21 438-444 (1998)
  9. IL-6 type cytokine receptor complexes: hexamer, tetramer or both? Grötzinger J, Kernebeck T, Kallen KJ, Rose-John S. Biol Chem 380 803-813 (1999)
  10. Signaling mechanisms through cytokine receptors that share signal transducing receptor components. Taga T, Kishimoto T. Curr Opin Immunol 7 17-23 (1995)
  11. Four-helix bundle growth factors and their receptors: protein-protein interactions. Mott HR, Campbell ID. Curr Opin Struct Biol 5 114-121 (1995)
  12. Leukemia inhibitory factor: part of a large ingathering family. Taupin JL, Pitard V, Dechanet J, Miossec V, Gualde N, Moreau JF. Int Rev Immunol 16 397-426 (1998)
  13. Control of uterine receptivity and embryo implantation by steroid hormone regulation of LIF production and LIF receptor activity: towards a molecular understanding of "the window of implantation". Cheng JG, Rodriguez CI, Stewart CL. Rev Endocr Metab Disord 3 119-126 (2002)
  14. The emerging role of leukemia inhibitory factor in cancer and therapy. Zhang C, Liu J, Wang J, Hu W, Feng Z. Pharmacol Ther 221 107754 (2021)
  15. LIF (AM424), a promising growth factor for the treatment of ALS. Kurek JB, Radford AJ, Crump DE, Bower JJ, Feeney SJ, Austin L, Byrne E. J Neurol Sci 160 Suppl 1 S106-13 (1998)
  16. Activating mechanism of CNTF and related cytokines. Inoue M, Nakayama C, Noguchi H. Mol Neurobiol 12 195-209 (1996)
  17. Novel neurotrophin-1/B cell-stimulating factor-3 (NNT-1/BSF-3)/cardiotrophin-like cytokine (CLC)--a novel gp130 cytokine with pleiotropic functions. Vlotides G, Zitzmann K, Stalla GK, Auernhammer CJ. Cytokine Growth Factor Rev 15 325-336 (2004)
  18. Leukemia inhibitory factor: an important regulator of endometrial function. Kondera-Anasz Z, Sikora J, Mielczarek-Palacz A. Am J Reprod Immunol 52 97-105 (2004)
  19. Leukemia inhibitory factor, a double-edged sword with therapeutic implications in human diseases. Wang J, Chang CY, Yang X, Zhou F, Liu J, Feng Z, Hu W. Mol Ther 31 331-343 (2023)
  20. Interferons alpha/beta and their receptors: place in the hierarchy of cytokines. Zav'Yalov VP, Zav'Yalova GA. APMIS 105 161-186 (1997)
  21. Neurotrophic factors and the development of drugs to promote motoneuron survival. Hughes RA, O'Leary PD. Clin Exp Pharmacol Physiol 23 965-969 (1996)
  22. Stimulation of Osteoclast Formation by Oncostatin M and the Role of WNT16 as a Negative Feedback Regulator. de Souza PPC, Henning P, Lerner UH. Int J Mol Sci 23 3287 (2022)
  23. Structural aspects of cytokine/receptor interactions. Nicola NA. Ann N Y Acad Sci 766 253-262 (1995)

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