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Human SULT1A1 complexed with PAP and p-Nitrophenol

Source organism: Homo sapiens
Biochemical function: 3'-phosphoadenosine 5'-phosphosulfate binding
Biological process: sulfation
Cellular component: cytosol

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EC 2.8.2.1: Aryl sulfotransferase

Reaction catalysed:
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
Systematic name:
3'-phosphoadenylyl-sulfate:phenol sulfotransferase
Alternative Name(s):
  • 1-naphthol phenol sulfotransferase
  • 2-naphtholsulfotransferase
  • 4-nitrocatechol sulfokinase
  • Arylsulfotransferase
  • Dopamine sulfotransferase
  • PST
  • Phenol sulfokinase
  • Phenol sulfotransferase
  • Ritodrine sulfotransferase
  • Sulfokinase
  • p-nitrophenol sulfotransferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00685
Domain description: Sulfotransferase domain
Occurring in:
  1. Sulfotransferase 1A1
The deposited structure of PDB entry 1ls6 contains 1 copy of Pfam domain PF00685 (Sulfotransferase domain) in Sulfotransferase 1A1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Sulfotransferase 1A1
IPR000863
Domain description: Sulfotransferase domain
Occurring in:
  1. Sulfotransferase 1A1

Structure domain

CATH CATH domain
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Sulfotransferase 1A1
The deposited structure of PDB entry 1ls6 contains 1 copy of CATH domain 3.40.50.300 (Rossmann fold) in Sulfotransferase 1A1. Showing 1 copy in chain A.
SCOP SCOP annotation
52575
Class: Alpha and beta proteins (a/b)
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Occurring in:
  1. Sulfotransferase 1A1
The deposited structure of PDB entry 1ls6 contains 1 copy of SCOP domain 52575 (PAPS sulfotransferase) in Sulfotransferase 1A1. Showing 1 copy in chain A.

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