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The crystal structure of a mutant enzyme of Coprinus cinereus peroxidase provides an understanding of its increased thermostability and insight into modelling of protein structures

Source organism: Coprinopsis cinerea
Biochemical function: lactoperoxidase activity
Biological process: cellular oxidant detoxification
Cellular component: extracellular region

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EC 1.11.1.7: Peroxidase

Reaction catalysed:
2 phenolic donor + H(2)O(2) = 2 phenoxyl radical of the donor + 2 H(2)O
Systematic name:
Phenolic donor:hydrogen-peroxide oxidoreductase
Alternative Name(s):
  • Arthromyces ramosus peroxidase
  • Coprinus cinereus peroxidase
  • Extensin peroxidase
  • Guaiacol peroxidase
  • Heme peroxidase
  • Horseradish peroxidase (HRP)
  • Japanese radish peroxidase
  • Lactoperoxidase
  • Oxyperoxidase
  • Plant peroxidase
  • Protoheme peroxidase
  • Pyrocatechol peroxidase
  • Scopoletin peroxidase
  • Soybean peroxidase (SBP)

GO terms

Sequence families

Pfam Protein families (Pfam)
PF11895
Domain description: Fungal peroxidase extension region
Occurring in:
  1. Peroxidase
The deposited structure of PDB entry 1ly8 contains 2 copies of Pfam domain PF11895 (Fungal peroxidase extension region) in Peroxidase. Showing 1 copy in chain A.

PF00141
Domain description: Peroxidase
Occurring in:
  1. Peroxidase
The deposited structure of PDB entry 1ly8 contains 2 copies of Pfam domain PF00141 (Peroxidase) in Peroxidase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001621
Domain description: Fungal ligninase
Occurring in:
  1. Peroxidase
IPR002016
Domain description: Haem peroxidase
Occurring in:
  1. Peroxidase
IPR024589
Domain description: Fungal ligninase, C-terminal
Occurring in:
  1. Peroxidase
IPR019793
Domain description: Peroxidases heam-ligand binding site
Occurring in:
  1. Peroxidase
IPR019794
Domain description: Peroxidase, active site
Occurring in:
  1. Peroxidase
IPR044831
Domain description: Heme-binding peroxidase Ccp1-like
Occurring in:
  1. Peroxidase
IPR010255
Domain description: Haem peroxidase superfamily
Occurring in:
  1. Peroxidase

Structure domains

CATH CATH domains
1.10.420.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Peroxidase; domain 2
Homology: Peroxidase, domain 2
Occurring in:
  1. Peroxidase
The deposited structure of PDB entry 1ly8 contains 2 copies of CATH domain 1.10.420.10 (Peroxidase; domain 2) in Peroxidase. Showing 1 copy in chain A.
1.10.520.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Peroxidase; domain 1
Homology: Peroxidase; domain 1
Occurring in:
  1. Peroxidase
The deposited structure of PDB entry 1ly8 contains 2 copies of CATH domain 1.10.520.10 (Peroxidase; domain 1) in Peroxidase. Showing 1 copy in chain A.
SCOP SCOP annotation
48114
Class: All alpha proteins
Fold: Heme-dependent peroxidases
Superfamily: Heme-dependent peroxidases
Occurring in:
  1. Peroxidase
The deposited structure of PDB entry 1ly8 contains 2 copies of SCOP domain 48114 (CCP-like) in Peroxidase. Showing 1 copy in chain A.

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