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Biosynthetic thiolase, C89A mutant, complexed with acetyl coenzyme A

Source organism: Zoogloea ramigera
Biochemical function: acyltransferase activity, transferring groups other than amino-acyl groups
Biological process: poly-hydroxybutyrate biosynthetic process
Cellular component: cytoplasm

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EC 2.3.1.9: Acetyl-CoA C-acetyltransferase

Reaction catalysed:
(1a) acetyl-CoA + [acetyl-CoA C-acetyltransferase]-L-cysteine = [acetyl-CoA C-acetyltransferase]-S-acetyl-L-cysteine + CoA
Systematic name:
Acetyl-CoA:acetyl-CoA C-acetyltransferase
Alternative Name(s):
  • 2-methylacetoacetyl-CoA thiolase
  • 3-oxothiolase
  • Acetoacetyl-CoA thiolase
  • Acetyl coenzyme A thiolase
  • Acetyl-CoA acetyltransferase
  • Acetyl-CoA:N-acetyltransferase
  • Beta-acetoacetyl coenzyme A thiolase
  • Thiolase II

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02803
Domain description: Thiolase, C-terminal domain
Occurring in:
  1. Acetyl-CoA acetyltransferase
The deposited structure of PDB entry 1m3z contains 4 copies of Pfam domain PF02803 (Thiolase, C-terminal domain) in Acetyl-CoA acetyltransferase. Showing 1 copy in chain A.

PF00108
Domain description: Thiolase, N-terminal domain
Occurring in:
  1. Acetyl-CoA acetyltransferase
The deposited structure of PDB entry 1m3z contains 4 copies of Pfam domain PF00108 (Thiolase, N-terminal domain) in Acetyl-CoA acetyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR016039
Domain description: Thiolase-like
Occurring in:
  1. Acetyl-CoA acetyltransferase
IPR002155
Domain description: Thiolase
Occurring in:
  1. Acetyl-CoA acetyltransferase
IPR020610
Domain description: Thiolase, active site
Occurring in:
  1. Acetyl-CoA acetyltransferase
IPR020613
Domain description: Thiolase, conserved site
Occurring in:
  1. Acetyl-CoA acetyltransferase
IPR020617
Domain description: Thiolase, C-terminal
Occurring in:
  1. Acetyl-CoA acetyltransferase
IPR020616
Domain description: Thiolase, N-terminal
Occurring in:
  1. Acetyl-CoA acetyltransferase

Structure domain

CATH CATH domain
3.40.47.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Peroxisomal Thiolase; Chain A, domain 1
Homology: Peroxisomal Thiolase; Chain A, domain 1
Occurring in:
  1. Acetyl-CoA acetyltransferase
The deposited structure of PDB entry 1m3z contains 8 copies of CATH domain 3.40.47.10 (Peroxisomal Thiolase; Chain A, domain 1) in Acetyl-CoA acetyltransferase. Showing 2 copies in chain A.
SCOP SCOP annotation
53902
Class: Alpha and beta proteins (a/b)
Fold: Thiolase-like
Superfamily: Thiolase-like
Occurring in:
  1. Acetyl-CoA acetyltransferase
The deposited structure of PDB entry 1m3z contains 8 copies of SCOP domain 53902 (Thiolase-related) in Acetyl-CoA acetyltransferase. Showing 2 copies in chain A.

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