Function and Biology

Crystal Structure of Human IL-2 Complexed with (R)-N-[2-[1-(Aminoiminomethyl)-3-piperidinyl]-1-oxoethyl]-4-(phenylethynyl)-L-phenylalanine methyl ester

Source organism: Homo sapiens

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00715
Domain description: Interleukin 2
Occurring in:
  1. Interleukin-2
The deposited structure of PDB entry 1m48 contains 2 copies of Pfam domain PF00715 (Interleukin 2) in Interleukin-2. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000779
Domain description: Interleukin-2
Occurring in:
  1. Interleukin-2
IPR009079
Domain description: Four-helical cytokine-like, core
Occurring in:
  1. Interleukin-2
IPR030477
Domain description: Interleukin-2, conserved site
Occurring in:
  1. Interleukin-2

Structure domain

CATH CATH domain
1.20.1250.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Growth Hormone; Chain: A;
Homology: Growth Hormone; Chain: A;
Occurring in:
  1. Interleukin-2
The deposited structure of PDB entry 1m48 contains 2 copies of CATH domain 1.20.1250.10 (Growth Hormone; Chain: A;) in Interleukin-2. Showing 1 copy in chain B.
SCOP SCOP annotation
47286
Class: All alpha proteins
Fold: 4-helical cytokines
Superfamily: 4-helical cytokines
Occurring in:
  1. Interleukin-2
The deposited structure of PDB entry 1m48 contains 2 copies of SCOP domain 47286 (Short-chain cytokines) in Interleukin-2. Showing 1 copy in chain B.