› 1m4u

X-ray diffraction
2.42Å resolution

Crystal structure of Bone Morphogenetic Protein-7 (BMP-7) in complex with the secreted antagonist Noggin

Released:
DOI: 10.2210/pdb1m4u/pdb
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PDB entry 1m4u coloured by chain, front view.
PDB entry 1m4u coloured by chain, side view.
PDB entry 1m4u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of BMP signalling inhibition by the cystine knot protein Noggin.
Groppe J, Greenwald J, Wiater E, Rodriguez-Leon J, Economides AN, Kwiatkowski W, Affolter M, Vale WW, Izpisua Belmonte JC, Choe S
Nature 420 636-42 (2002)
PMID: 12478285

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148283 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Bone morphogenetic protein 7 Chain: L
Molecule details ›
Chain: L
Length: 139 amino acids
Theoretical weight: 15.7 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P18075 (Residues: 293-431; Coverage: 35%)
Gene names: BMP7, OP1
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines
Noggin Chain: A
Molecule details ›
Chain: A
Length: 206 amino acids
Theoretical weight: 23.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13253 (Residues: 28-232; Coverage: 100%)
Gene name: NOG
Sequence domains: Noggin
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P41212
Unit cell:
a: 99.834Å b: 99.834Å c: 150.327Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.241 0.273
Expression systems:
  • Cricetulus griseus
  • Escherichia coli

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Citations

73 review citations

Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
Shi et al. (2003)
72 more

29 mentions without citation

Structural Biology and Evolution of the TGF-β Family.
Hinck et al. (2016)
28 more

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