EC 4.1.1.32: Phosphoenolpyruvate carboxykinase (GTP)
Reaction catalysed:
GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO(2)
Systematic name:
GTP:oxaloacetate carboxy-lyase (adding GTP; phosphoenolpyruvate-forming)
Alternative Name(s):
- GTP:oxaloacetate carboxy-lyase (transphosphorylating)
- PEP carboxykinase
- PEP carboxylase
- PEPCK
- Phosphoenolpyruvate carboxykinase
- Phosphoenolpyruvate carboxylase
- Phosphoenolpyruvic carboxykinase
- Phosphoenolpyruvic carboxykinase (GTP)
- Phosphoenolpyruvic carboxylase (GTP)
- Phosphopyruvate (guanosine triphosphate) carboxykinase
- Phosphopyruvate carboxylase
- Phosphopyruvate carboxylase (GTP)
GO terms
Biochemical function:
- protein serine kinase activity (using GTP as donor)
- metal ion binding
- carboxylic acid binding
- manganese ion binding
- GDP binding
- purine nucleotide binding
- carboxy-lyase activity
- kinase activity
- GTP binding
- phosphoenolpyruvate carboxykinase (GTP) activity
- phosphoenolpyruvate carboxykinase activity
- magnesium ion binding
Biological process:
- response to methionine
- cellular response to phorbol 13-acetate 12-myristate
- cellular response to raffinose
- tricarboxylic acid metabolic process
- cellular response to dexamethasone stimulus
- cellular hypotonic salinity response
- cellular hypotonic response
- cellular hyperosmotic salinity response
- cellular hyperosmotic response
- cellular response to hypoxia
- cellular response to glucagon stimulus
- cellular response to tumor necrosis factor
- cellular response to interleukin-1
- cellular response to glucose stimulus
- cellular response to fructose stimulus
- cellular response to cAMP
- cellular response to retinoic acid
- response to interleukin-6
- hepatocyte differentiation
- cellular response to potassium ion starvation
- regulation of lipid biosynthetic process
- positive regulation of lipid biosynthetic process
- glycerol biosynthetic process from pyruvate
- glyceraldehyde-3-phosphate biosynthetic process
- positive regulation of transcription by RNA polymerase II
- dicarboxylic acid metabolic process
- positive regulation of memory T cell differentiation
- response to starvation
- glucose homeostasis
- response to lipid
- cellular response to insulin stimulus
- response to insulin
- response to lipopolysaccharide
- response to nutrient levels
- propionate catabolic process
- peptidyl-serine phosphorylation
- phosphorylation
- response to activity
- response to bacterium
- lipid metabolic process
- oxaloacetate metabolic process
- gluconeogenesis
- glucose metabolic process
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
IPR018091
Domain description:
Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site
Occurring in:
Occurring in:
IPR035077
Domain description:
Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain
Occurring in:
Occurring in:
Structure domains
CATH domains
3.90.228.20
Class:
Alpha Beta
Architecture:
Alpha-Beta Complex
Topology:
Phosphoenolpyruvate Carboxykinase; domain 3
Homology:
Phosphoenolpyruvate Carboxykinase; domain 3
Occurring in:
2.170.8.10
Class:
Mainly Beta
Architecture:
Beta Complex
Topology:
Phosphoenolpyruvate Carboxykinase; domain 2
Homology:
Phosphoenolpyruvate Carboxykinase, domain 2
Occurring in: