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Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

Source organisms:
Biochemical function: cyclosporin A binding
Biological process: calcineurin-mediated signaling
Cellular component: cytosol

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EC 5.2.1.8: Peptidylprolyl isomerase

Reaction catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0)
Systematic name:
Peptidylproline cis-trans-isomerase
Alternative Name(s):
  • Cyclophilin
  • PPIase
  • Peptide bond isomerase
  • Peptidyl-prolyl cis-trans isomerase
  • Peptidylprolyl cis-trans isomerase
  • Rotamase

EC 3.1.3.16: Protein-serine/threonine phosphatase

Reaction catalysed:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Systematic name:
Phosphoprotein phosphohydrolase
Alternative Name(s):
  • 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase
  • Aspergillus awamori acid protein phosphatase
  • BCKDH phosphatase
  • Branched-chain alpha-keto acid dehydrogenase phosphatase
  • Calcineurin
  • Casein phosphatase
  • HMG-CoA reductase phosphatase
  • Phosphatase 2A
  • Phosphatase 2B
  • Phosphatase C-II
  • Phosphatase H-II
  • Phosphatase I
  • Phosphatase IB
  • Phosphatase II
  • Phosphatase III
  • Phosphatase IV
  • Phosphatase SP
  • Phosphoprotein phosphatase
  • Phosphopyruvate dehydrogenase phosphatase
  • Phosphospectrin phosphatase
  • Polycation modulated (PCM-) phosphatase
  • Protein D phosphatase
  • Protein phosphatase
  • Protein phosphatase-1
  • Protein phosphatase-2A
  • Protein phosphatase-2B
  • Protein phosphatase-2C
  • Serine/threonine specific protein phosphatase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF13499
Domain description: EF-hand domain pair
Occurring in:
  1. Calcineurin subunit B type 1
The deposited structure of PDB entry 1m63 contains 4 copies of Pfam domain PF13499 (EF-hand domain pair) in Calcineurin subunit B type 1. Showing 2 copies in chain F.

PF00160
Domain description: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Occurring in:
  1. Peptidyl-prolyl cis-trans isomerase A
The deposited structure of PDB entry 1m63 contains 2 copies of Pfam domain PF00160 (Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD) in Peptidyl-prolyl cis-trans isomerase A. Showing 1 copy in chain C.

PF00149
Domain description: Calcineurin-like phosphoesterase
Occurring in:
  1. Protein phosphatase 3 catalytic subunit alpha
The deposited structure of PDB entry 1m63 contains 2 copies of Pfam domain PF00149 (Calcineurin-like phosphoesterase) in Protein phosphatase 3 catalytic subunit alpha. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002048
Domain description: EF-hand domain
Occurring in:
  1. Calcineurin subunit B type 1
IPR006186
Domain description: Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Occurring in:
  1. Protein phosphatase 3 catalytic subunit alpha
IPR002130
Domain description: Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
Occurring in:
  1. Peptidyl-prolyl cis-trans isomerase A
IPR018247
Domain description: EF-Hand 1, calcium-binding site
Occurring in:
  1. Calcineurin subunit B type 1
IPR029000
Domain description: Cyclophilin-like domain superfamily
Occurring in:
  1. Peptidyl-prolyl cis-trans isomerase A
IPR029052
Domain description: Metallo-dependent phosphatase-like
Occurring in:
  1. Protein phosphatase 3 catalytic subunit alpha
IPR020892
Domain description: Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
Occurring in:
  1. Peptidyl-prolyl cis-trans isomerase A
IPR024936
Domain description: Cyclophilin-type peptidyl-prolyl cis-trans isomerase
Occurring in:
  1. Peptidyl-prolyl cis-trans isomerase A
IPR011992
Domain description: EF-hand domain pair
Occurring in:
  1. Calcineurin subunit B type 1
IPR015757
Domain description: Calcineurin B protein
Occurring in:
  1. Calcineurin subunit B type 1
IPR004843
Domain description: Calcineurin-like phosphoesterase domain, ApaH type
Occurring in:
  1. Protein phosphatase 3 catalytic subunit alpha
IPR041751
Domain description: PP2B, metallophosphatase domain
Occurring in:
  1. Protein phosphatase 3 catalytic subunit alpha
IPR043360
Domain description: PP2B
Occurring in:
  1. Protein phosphatase 3 catalytic subunit alpha

Structure domains

CATH CATH domains
2.40.100.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Cyclophilin
Homology: Cyclophilin-like
Occurring in:
  1. Peptidyl-prolyl cis-trans isomerase A
The deposited structure of PDB entry 1m63 contains 2 copies of CATH domain 2.40.100.10 (Cyclophilin) in Peptidyl-prolyl cis-trans isomerase A. Showing 1 copy in chain C.
1.10.238.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Recoverin; domain 1
Homology: EF-hand
Occurring in:
  1. Calcineurin subunit B type 1
The deposited structure of PDB entry 1m63 contains 2 copies of CATH domain 1.10.238.10 (Recoverin; domain 1) in Calcineurin subunit B type 1. Showing 1 copy in chain F.
3.60.21.10
Class: Alpha Beta
Architecture: 4-Layer Sandwich
Topology: Purple Acid Phosphatase; chain A, domain 2
Homology: Purple Acid Phosphatase; chain A, domain 2
Occurring in:
  1. Protein phosphatase 3 catalytic subunit alpha
The deposited structure of PDB entry 1m63 contains 2 copies of CATH domain 3.60.21.10 (Purple Acid Phosphatase; chain A, domain 2) in Protein phosphatase 3 catalytic subunit alpha. Showing 1 copy in chain A.
SCOP SCOP annotations
50892
Class: All beta proteins
Fold: Cyclophilin-like
Superfamily: Cyclophilin-like
Occurring in:
  1. Peptidyl-prolyl cis-trans isomerase A
The deposited structure of PDB entry 1m63 contains 2 copies of SCOP domain 50892 (Cyclophilin (peptidylprolyl isomerase)) in Peptidyl-prolyl cis-trans isomerase A. Showing 1 copy in chain C.
47502
Class: All alpha proteins
Fold: EF Hand-like
Superfamily: EF-hand
Occurring in:
  1. Calcineurin subunit B type 1
The deposited structure of PDB entry 1m63 contains 2 copies of SCOP domain 47502 (Calmodulin-like) in Calcineurin subunit B type 1. Showing 1 copy in chain F.
56310
Class: Alpha and beta proteins (a+b)
Fold: Metallo-dependent phosphatases
Superfamily: Metallo-dependent phosphatases
Occurring in:
  1. Protein phosphatase 3 catalytic subunit alpha
The deposited structure of PDB entry 1m63 contains 2 copies of SCOP domain 56310 (Protein serine/threonine phosphatase) in Protein phosphatase 3 catalytic subunit alpha. Showing 1 copy in chain A.

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