› 1m7b

X-ray diffraction
2Å resolution

Crystal structure of Rnd3/RhoE: functional implications

Released:
DOI: 10.2210/pdb1m7b/pdb
PDB entry 1m7b coloured by chain, front view.
PDB entry 1m7b coloured by chain, side view.
PDB entry 1m7b coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of Rnd3/RhoE: functional implications.
Fiegen D, Blumenstein L, Stege P, Vetter IR, Ahmadian MR
FEBS Lett 525 100-4 (2002)
PMID: 12163169

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158293 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rho-related GTP-binding protein RhoE Chain: A
Molecule details ›
Chain: A
Length: 184 amino acids
Theoretical weight: 20.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61587 (Residues: 19-200; Coverage: 75%)
Gene names: ARHE, RHO8, RHOE, RND3
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand GTP 1 x GTP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR591
Spacegroup: I222
Unit cell:
a: 63.592Å b: 69.932Å c: 97.715Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.201 0.243
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

GDIs: central regulatory molecules in Rho GTPase activation.
DerMardirossian et al. (2005)
6 more

7 mentions without citation

Predicting new indications for approved drugs using a proteochemometric method.
Dakshanamurthy et al. (2012)
6 more