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Regulatory Segment of Mouse 3',5'-Cyclic Nucleotide Phosphodiesterase 2A, Containing the GAF A and GAF B Domains

Source organism: Mus musculus
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase

Reaction catalysed:
Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate
Systematic name:
3',5'-cyclic-nucleotide 5'-nucleotidohydrolase
Alternative Name(s):
  • 3', 5'-cyclic nucleoside monophosphate phosphodiesterase
  • 3',5'-cyclonucleotide phosphodiesterase
  • 3',5'-nucleotide phosphodiesterase
  • 3': 5'-monophosphate phosphodiesterase (cyclic CMP)
  • 3':5'-cyclic nucleotide 5'-nucleotidohydrolase
  • Cyclic 3',5'-mononucleotide phosphodiesterase
  • Cyclic 3',5'-nucleotide phosphodiesterase
  • Cyclic 3',5'-phosphodiesterase
  • Cyclic 3',5-nucleotide monophosphate phosphodiesterase
  • Cyclic AMP phosphodiesterase
  • Cyclic nucleotide phosphodiesterase
  • Cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP)
  • Nucleoside 3',5'-cyclic phosphate diesterase
  • Nucleoside-3',5-monophosphate phosphodiesterase
  • PDE

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF01590
Domain description: GAF domain
Occurring in:
  1. cGMP-dependent 3',5'-cyclic phosphodiesterase
The deposited structure of PDB entry 1mc0 contains 1 copy of Pfam domain PF01590 (GAF domain) in cGMP-dependent 3',5'-cyclic phosphodiesterase. Showing 1 copy in chain A.

PF13185
Domain description: GAF domain
Occurring in:
  1. cGMP-dependent 3',5'-cyclic phosphodiesterase
The deposited structure of PDB entry 1mc0 contains 1 copy of Pfam domain PF13185 (GAF domain) in cGMP-dependent 3',5'-cyclic phosphodiesterase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003018
Domain description: GAF domain
Occurring in:
  1. cGMP-dependent 3',5'-cyclic phosphodiesterase
IPR029016
Domain description: GAF-like domain superfamily
Occurring in:
  1. cGMP-dependent 3',5'-cyclic phosphodiesterase

Structure domain

CATH CATH domain
3.30.450.40
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Beta-Lactamase
Homology: Beta-Lactamase
Occurring in:
  1. cGMP-dependent 3',5'-cyclic phosphodiesterase
The deposited structure of PDB entry 1mc0 contains 2 copies of CATH domain 3.30.450.40 (Beta-Lactamase) in cGMP-dependent 3',5'-cyclic phosphodiesterase. Showing 2 copies in chain A.
SCOP SCOP annotation
55782
Class: Alpha and beta proteins (a+b)
Fold: Profilin-like
Superfamily: GAF domain-like
Occurring in:
  1. cGMP-dependent 3',5'-cyclic phosphodiesterase
The deposited structure of PDB entry 1mc0 contains 2 copies of SCOP domain 55782 (GAF domain) in cGMP-dependent 3',5'-cyclic phosphodiesterase. Showing 2 copies in chain A.

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