Function and Biology

CRYSTAL STRUCTURE OF MYOD BHLH DOMAIN BOUND TO DNA: PERSPECTIVES ON DNA RECOGNITION AND IMPLICATIONS FOR TRANSCRIPTIONAL ACTIVATION

Source organism: Mus musculus
Biochemical function: protein dimerization activity
Biological process: muscle organ development
Cellular component: not assigned

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00010
Domain description: Helix-loop-helix DNA-binding domain
Occurring in:
  1. Myoblast determination protein 1
  2. Myoblast determination protein 1
The deposited structure of PDB entry 1mdy contains 1 copy of Pfam domain PF00010 (Helix-loop-helix DNA-binding domain) in Myoblast determination protein 1. Showing 1 copy in chain E [auth A].
The deposited structure of PDB entry 1mdy contains 3 copies of Pfam domain PF00010 (Helix-loop-helix DNA-binding domain) in Myoblast determination protein 1. Showing 1 copy in chain F [auth B].

InterPro InterPro annotations
IPR011598
Domain description: Myc-type, basic helix-loop-helix (bHLH) domain
Occurring in:
  1. Myoblast determination protein 1
  2. Myoblast determination protein 1
IPR036638
Domain description: Helix-loop-helix DNA-binding domain superfamily
Occurring in:
  1. Myoblast determination protein 1
  2. Myoblast determination protein 1
IPR039704
Domain description: Myogenic factor
Occurring in:
  1. Myoblast determination protein 1
  2. Myoblast determination protein 1

Structure domain

CATH CATH domain
4.10.280.10
Class: Few Secondary Structures
Architecture: Irregular
Topology: MYOD Basic-Helix-Loop-Helix Domain, subunit B
Homology: Helix-loop-helix DNA-binding domain
Occurring in:
  1. Myoblast determination protein 1
  2. Myoblast determination protein 1
The deposited structure of PDB entry 1mdy contains 1 copy of CATH domain 4.10.280.10 (MYOD Basic-Helix-Loop-Helix Domain, subunit B) in Myoblast determination protein 1. Showing 1 copy in chain E [auth A].
The deposited structure of PDB entry 1mdy contains 3 copies of CATH domain 4.10.280.10 (MYOD Basic-Helix-Loop-Helix Domain, subunit B) in Myoblast determination protein 1. Showing 1 copy in chain F [auth B].
SCOP SCOP annotation
47460
Class: All alpha proteins
Fold: HLH-like
Superfamily: HLH, helix-loop-helix DNA-binding domain
Occurring in:
  1. Myoblast determination protein 1
  2. Myoblast determination protein 1
The deposited structure of PDB entry 1mdy contains 1 copy of SCOP domain 47460 (HLH, helix-loop-helix DNA-binding domain) in Myoblast determination protein 1. Showing 1 copy in chain E [auth A].
The deposited structure of PDB entry 1mdy contains 3 copies of SCOP domain 47460 (HLH, helix-loop-helix DNA-binding domain) in Myoblast determination protein 1. Showing 1 copy in chain F [auth B].