› 1mld

X-ray diffraction
1.83Å resolution

REFINED STRUCTURE OF MITOCHONDRIAL MALATE DEHYDROGENASE FROM PORCINE HEART AND THE CONSENSUS STRUCTURE FOR DICARBOXYLIC ACID OXIDOREDUCTASES

Released:
DOI: 10.2210/pdb1mld/pdb
PDB entry 1mld coloured by chain, front view.
PDB entry 1mld coloured by chain, side view.
PDB entry 1mld coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
Refined crystal structure of mitochondrial malate dehydrogenase from porcine heart and the consensus structure for dicarboxylic acid oxidoreductases.
Gleason WB, Fu Z, Birktoft J, Banaszak L
Biochemistry 33 2078-88 (1994)
PMID: 8117664

Function and Biology Details

Reaction catalysed: 
(S)-malate + NAD(+) = oxaloacetate + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-132420 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Malate dehydrogenase, mitochondrial Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 314 amino acids
Theoretical weight: 33.12 KDa
Source organism: Sus scrofa
Expression system: Not provided
UniProt:
  • Canonical: P00346 (Residues: 25-338; Coverage: 93%)
Gene name: MDH2
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CIT 4 x CIT
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 72.75Å b: 146.76Å c: 67.58Å
α: 90° β: 108.16° γ: 90°
R-values:
R R work R free
0.211 0.211 not available
Expression system: Not provided

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Citations

36 citation in other articles

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling.
Guex et al. (1997)
35 more

22 mentions without citation

An evolving view of complex II-noncanonical complexes, megacomplexes, respiration, signaling, and beyond.
Iverson et al. (2023)
21 more