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CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE

Source organism: Rattus norvegicus
Biochemical function: monoacylglycerol lipase activity
Biological process: regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
Cellular component: glutamatergic synapse

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EC 3.5.1.99: Fatty acid amide hydrolase

Reaction catalysed:
Anandamide + H(2)O = arachidonic acid + ethanolamine
Systematic name:
Fatty acylamide amidohydrolase
Alternative Name(s):
  • Anandamide amidohydrolase
  • FAAH
  • Oleamide hydrolase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01425
Domain description: Amidase
Occurring in:
  1. Fatty-acid amide hydrolase 1
The deposited structure of PDB entry 1mt5 contains 16 copies of Pfam domain PF01425 (Amidase) in Fatty-acid amide hydrolase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036928
Domain description: Amidase signature (AS) superfamily
Occurring in:
  1. Fatty-acid amide hydrolase 1
IPR020556
Domain description: Amidase, conserved site
Occurring in:
  1. Fatty-acid amide hydrolase 1
IPR023631
Domain description: Amidase signature domain
Occurring in:
  1. Fatty-acid amide hydrolase 1

Structure domain

CATH CATH domain
3.90.1300.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Amidase signature (AS) enzymes
Homology: Amidase signature (AS) domain
Occurring in:
  1. Fatty-acid amide hydrolase 1
The deposited structure of PDB entry 1mt5 contains 16 copies of CATH domain 3.90.1300.10 (Amidase signature (AS) enzymes) in Fatty-acid amide hydrolase 1. Showing 1 copy in chain A.
SCOP SCOP annotation
75305
Class: Alpha and beta proteins (a/b)
Fold: Amidase signature (AS) enzymes
Superfamily: Amidase signature (AS) enzymes
Occurring in:
  1. Fatty-acid amide hydrolase 1
The deposited structure of PDB entry 1mt5 contains 16 copies of SCOP domain 75305 (Amidase signature (AS) enzymes) in Fatty-acid amide hydrolase 1. Showing 1 copy in chain A.

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