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Crystal structure of a Phosphofructokinase mutant from Bacillus stearothermophilus bound with fructose-6-phosphate

Source organism: Geobacillus stearothermophilus
Biochemical function: fructose-6-phosphate binding
Biological process: canonical glycolysis
Cellular component: 6-phosphofructokinase complex

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EC 2.7.1.11: 6-phosphofructokinase

Reaction catalysed:
ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate
Systematic name:
ATP:beta-D-fructose-6-phosphate 1-phosphotransferase
Alternative Name(s):
  • 6-phosphofructose 1-kinase
  • ATP-dependent phosphofructokinase
  • D-fructose-6-phosphate 1-phosphotransferase
  • Fructose 6-phosphate kinase
  • Fructose 6-phosphokinase
  • Nucleotide triphosphate-dependent phosphofructokinase
  • PFK
  • Phospho-1,6-fructokinase
  • Phosphofructokinase (phosphorylating)
  • Phosphofructokinase I
  • Phosphohexokinase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00365
Domain description: Phosphofructokinase
Occurring in:
  1. ATP-dependent 6-phosphofructokinase
The deposited structure of PDB entry 1mto contains 8 copies of Pfam domain PF00365 (Phosphofructokinase) in ATP-dependent 6-phosphofructokinase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR022953
Domain description: ATP-dependent 6-phosphofructokinase
Occurring in:
  1. ATP-dependent 6-phosphofructokinase
IPR012828
Domain description: ATP-dependent 6-phosphofructokinase, prokaryotic
Occurring in:
  1. ATP-dependent 6-phosphofructokinase
IPR035966
Domain description: Phosphofructokinase superfamily
Occurring in:
  1. ATP-dependent 6-phosphofructokinase
IPR015912
Domain description: Phosphofructokinase, conserved site
Occurring in:
  1. ATP-dependent 6-phosphofructokinase
IPR000023
Domain description: Phosphofructokinase domain
Occurring in:
  1. ATP-dependent 6-phosphofructokinase
IPR012003
Domain description: ATP-dependent 6-phosphofructokinase, prokaryotic-type
Occurring in:
  1. ATP-dependent 6-phosphofructokinase

Structure domains

CATH CATH domains
3.40.50.460
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Phosphofructokinase domain
Occurring in:
  1. ATP-dependent 6-phosphofructokinase
The deposited structure of PDB entry 1mto contains 8 copies of CATH domain 3.40.50.460 (Rossmann fold) in ATP-dependent 6-phosphofructokinase. Showing 1 copy in chain A.
3.40.50.450
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. ATP-dependent 6-phosphofructokinase
The deposited structure of PDB entry 1mto contains 8 copies of CATH domain 3.40.50.450 (Rossmann fold) in ATP-dependent 6-phosphofructokinase. Showing 1 copy in chain A.
SCOP SCOP annotation
53785
Class: Alpha and beta proteins (a/b)
Fold: Phosphofructokinase
Superfamily: Phosphofructokinase
Occurring in:
  1. ATP-dependent 6-phosphofructokinase
The deposited structure of PDB entry 1mto contains 8 copies of SCOP domain 53785 (Phosphofructokinase) in ATP-dependent 6-phosphofructokinase. Showing 1 copy in chain A.

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