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The Crystal Structure of Pyruvoyl-dependent Arginine Decarboxylase from Methanococcus jannashii

Source organism: Methanocaldococcus jannaschii
Biochemical function: carboxy-lyase activity
Biological process: arginine catabolic process
Cellular component: not assigned

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EC 4.1.1.19: Arginine decarboxylase

Reaction catalysed:
L-arginine = agmatine + CO(2)
Systematic name:
L-arginine carboxy-lyase (agmatine-forming)
Alternative Name(s):
  • L-arginine carboxy-lyase
  • SpeA

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF01862
Domain description: Pyruvoyl-dependent arginine decarboxylase (PvlArgDC)
Occurring in:
  1. Pyruvoyl-dependent arginine decarboxylase subunit alpha
The deposited structure of PDB entry 1n13 contains 6 copies of Pfam domain PF01862 (Pyruvoyl-dependent arginine decarboxylase (PvlArgDC)) in Pyruvoyl-dependent arginine decarboxylase subunit alpha. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR002724
Domain description: Pyruvoyl-dependent arginine decarboxylase
Occurring in:
  1. Pyruvoyl-dependent arginine decarboxylase subunit beta
  2. Pyruvoyl-dependent arginine decarboxylase subunit alpha
IPR016104
Domain description: Pyruvoyl-dependent histidine/arginine decarboxylase
Occurring in:
  1. Pyruvoyl-dependent arginine decarboxylase subunit beta
  2. Pyruvoyl-dependent arginine decarboxylase subunit alpha
IPR016105
Domain description: Pyruvoyl-dependent histidine/arginine decarboxylase, 3-layer sandwich domain
Occurring in:
  1. Pyruvoyl-dependent arginine decarboxylase subunit alpha

Structure domains

CATH CATH domains
3.50.20.10
Class: Alpha Beta
Architecture: 3-Layer(bba) Sandwich
Topology: Pyruvoyl-Dependent Histidine Decarboxylase; Chain B
Homology: Pyruvoyl-Dependent Histidine Decarboxylase, subunit B
Occurring in:
  1. Pyruvoyl-dependent arginine decarboxylase subunit alpha
The deposited structure of PDB entry 1n13 contains 6 copies of CATH domain 3.50.20.10 (Pyruvoyl-Dependent Histidine Decarboxylase; Chain B) in Pyruvoyl-dependent arginine decarboxylase subunit alpha. Showing 1 copy in chain B.
3.30.60.30
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Wheat Germ Agglutinin (Isolectin 2); domain 1
Homology: Wheat Germ Agglutinin (Isolectin 2); domain 1
Occurring in:
  1. Pyruvoyl-dependent arginine decarboxylase subunit beta
The deposited structure of PDB entry 1n13 contains 6 copies of CATH domain 3.30.60.30 (Wheat Germ Agglutinin (Isolectin 2); domain 1) in Pyruvoyl-dependent arginine decarboxylase subunit beta. Showing 1 copy in chain E.
SCOP SCOP annotation
90046
Class: Alpha and beta proteins (a+b)
Fold: Pyruvoyl-dependent histidine and arginine decarboxylases
Superfamily: Pyruvoyl-dependent histidine and arginine decarboxylases
Occurring in:
  1. Pyruvoyl-dependent arginine decarboxylase subunit beta
  2. Pyruvoyl-dependent arginine decarboxylase subunit alpha
The deposited structure of PDB entry 1n13 contains 6 copies of SCOP domain 90046 (Arginine decarboxylase) in Pyruvoyl-dependent arginine decarboxylase subunit beta. Showing 1 copy in chain E.

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