› 1n8q

X-ray diffraction
2.1Å resolution

LIPOXYGENASE IN COMPLEX WITH PROTOCATECHUIC ACID

Released:
DOI: 10.2210/pdb1n8q/pdb
PDB entry 1n8q coloured by chain, front view.
PDB entry 1n8q coloured by chain, side view.
PDB entry 1n8q coloured by chain, top view.
Source organism: Glycine max
Primary publication:
Lipoxygenase interactions with natural flavonoid, quercetin, reveal a complex with protocatechuic acid in its X-ray structure at 2.1 A resolution.
Borbulevych OY, Jankun J, Selman SH, Skrzypczak-Jankun E
Proteins 54 13-9 (2004)
PMID: 14705020

Function and Biology Details

Reaction catalysed: 
Linoleate + O(2) = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-531099 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Seed linoleate 9S-lipoxygenase-3 Chain: A
Molecule details ›
Chain: A
Length: 857 amino acids
Theoretical weight: 96.92 KDa
Source organism: Glycine max
UniProt:
  • Canonical: P09186 (Residues: 1-857; Coverage: 100%)
Gene names: LOX1.3, LOX3
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand FE2 1 x FE2
Ligand DHB 1 x DHB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: C2
Unit cell:
a: 112.645Å b: 136.961Å c: 61.799Å
α: 90° β: 95.48° γ: 90°
R-values:
R R work R free
0.192 0.189 0.245

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Citations

4 review citations

Resveratrol: from diet to topical usage.
Chedea et al. (2017)
3 more

21 mentions without citation

Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines.
Jantan et al. (2014)
20 more