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PDZ tandem of human syntenin: crystal structure and functional properties.

Kang BS, Cooper DR, Jelen F, Devedjiev Y, Derewenda U, Dauter Z, Otlewski J, Derewenda ZS
Structure 11 459-68 (2003)
Cited: 67 times
EuropePMC logo PMID: 12679023

Abstract

Syntenin, a 33 kDa protein, interacts with several cell membrane receptors and with merlin, the product of the causal gene for neurofibromatosis type II. We report a crystal structure of the functional fragment of human syntenin containing two canonical PDZ domains, as well as binding studies for full-length syntenin, the PDZ tandem, and isolated PDZ domains. We show that the functional properties of syntenin are a result of independent interactions with target peptides, and that each domain is able to bind peptides belonging to two different classes: PDZ1 binds peptides from classes I and III, while PDZ2 interacts with classes I and II. The independent binding of merlin by PDZ1 and syndecan-4 by PDZ2 provides direct evidence for the coupling of syndecan-mediated signaling to actin regulation by merlin.

Articles - 1n99 mentioned but not cited (8)

  1. Domain orientation in the N-Terminal PDZ tandem from PSD-95 is maintained in the full-length protein. McCann JJ, Zheng L, Chiantia S, Bowen ME. Structure 19 810-820 (2011)
  2. Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling. Egea-Jimenez AL, Gallardo R, Garcia-Pino A, Ivarsson Y, Wawrzyniak AM, Kashyap R, Loris R, Schymkowitz J, Rousseau F, Zimmermann P. Nat Commun 7 12101 (2016)
  3. The role of the interactome in the maintenance of deleterious variability in human populations. Garcia-Alonso L, Jiménez-Almazán J, Carbonell-Caballero J, Vela-Boza A, Santoyo-López J, Antiñolo G, Dopazo J. Mol Syst Biol 10 752 (2014)
  4. Tetraspanin 6 is a regulator of carcinogenesis in colorectal cancer. Andrijes R, Hejmadi RK, Pugh M, Rajesh S, Novitskaya V, Ibrahim M, Overduin M, Tselepis C, Middleton GW, Győrffy B, Beggs AD, Berditchevski F. Proc Natl Acad Sci U S A 118 e2011411118 (2021)
  5. Syntenin is involved in the bacteria clearance response of kuruma shrimp (Marsupenaeus japonicus). Liu Q, Chen XW, Che CJ, Ding D, Kang CJ. Fish Shellfish Immunol 44 453-461 (2015)
  6. The Chlamydia trachomatis Protease CPAF Contains a Cryptic PDZ-Like Domain with Similarity to Human Cell Polarity and Tight Junction PDZ-Containing Proteins. Maksimchuk KR, Alser KA, Mou R, Valdivia RH, McCafferty DG. PLoS One 11 e0147233 (2016)
  7. CARDIO-PRED: an in silico tool for predicting cardiovascular-disorder associated proteins. Jain P, Thukral N, Gahlot LK, Hasija Y. Syst Synth Biol 9 55-66 (2015)
  8. Interaction between SARS-CoV PBM and Cellular PDZ Domains Leading to Virus Virulence. Honrubia JM, Valverde JR, Muñoz-Santos D, Ripoll-Gómez J, de la Blanca N, Izquierdo J, Villarejo-Torres M, Marchena-Pasero A, Rueda-Huélamo M, Nombela I, Ruiz-Yuste M, Zuñiga S, Sola I, Enjuanes L. Viruses 16 1214 (2024)


Reviews citing this publication (14)

  1. Transmembrane signaling proteoglycans. Couchman JR. Annu Rev Cell Dev Biol 26 89-114 (2010)
  2. Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density. Feng W, Zhang M. Nat Rev Neurosci 10 87-99 (2009)
  3. Peptidic modulators of protein-protein interactions: progress and challenges in computational design. Rubinstein M, Niv MY. Biopolymers 91 505-513 (2009)
  4. The trick of the tail: protein-protein interactions of metabotropic glutamate receptors. Enz R. Bioessays 29 60-73 (2007)
  5. PDZ Domains as Drug Targets. Christensen NR, Čalyševa J, Fernandes EFA, Lüchow S, Clemmensen LS, Haugaard-Kedström LM, Strømgaard K. Adv Ther (Weinh) 2 1800143 (2019)
  6. Targeting tumor invasion: the roles of MDA-9/Syntenin. Kegelman TP, Das SK, Emdad L, Hu B, Menezes ME, Bhoopathi P, Wang XY, Pellecchia M, Sarkar D, Fisher PB. Expert Opin Ther Targets 19 97-112 (2015)
  7. Emerging Themes in PDZ Domain Signaling: Structure, Function, and Inhibition. Liu X, Fuentes EJ. Int Rev Cell Mol Biol 343 129-218 (2019)
  8. WW or WoW: the WW domains in a union of bliss. Sudol M, Recinos CC, Abraczinskas J, Humbert J, Farooq A. IUBMB Life 57 773-778 (2005)
  9. MDA-9/Syntenin (SDCBP): Novel gene and therapeutic target for cancer metastasis. Das SK, Maji S, Wechman SL, Bhoopathi P, Pradhan AK, Talukdar S, Sarkar D, Landry J, Guo C, Wang XY, Cavenee WK, Emdad L, Fisher PB. Pharmacol Res 155 104695 (2020)
  10. MDA-9/Syntenin/SDCBP: new insights into a unique multifunctional scaffold protein. Pradhan AK, Maji S, Das SK, Emdad L, Sarkar D, Fisher PB. Cancer Metastasis Rev 39 769-781 (2020)
  11. Syntenin: PDZ Protein Regulating Signaling Pathways and Cellular Functions. Shimada T, Yasuda S, Sugiura H, Yamagata K. Int J Mol Sci 20 E4171 (2019)
  12. A PDZ Protein MDA-9/Syntenin: As a Target for Cancer Therapy. Yu Y, Li S, Wang K, Wan X. Comput Struct Biotechnol J 17 136-141 (2019)
  13. The Multifunctional Protein Syntenin-1: Regulator of Exosome Biogenesis, Cellular Function, and Tumor Progression. Lee KM, Seo EC, Lee JH, Kim HJ, Hwangbo C. Int J Mol Sci 24 9418 (2023)
  14. Biological Role and Aberrant Overexpression of Syntenin-1 in Cancer: Potential Role as a Biomarker and Therapeutic Target. Pintor-Romero VG, Hurtado-Ortega E, Nicolás-Morales ML, Gutiérrez-Torres M, Vences-Velázquez A, Ortuño-Pineda C, Espinoza-Rojo M, Navarro-Tito N, Cortés-Sarabia K. Biomedicines 11 1034 (2023)

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