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THE CRYSTAL STRUCTURE OF RECOMBINANT HUMAN NEUTROPHIL-ACTIVATING PEPTIDE-2 (M6L) AT 1.9-ANGSTROMS RESOLUTION

Source organism: Homo sapiens
Biochemical function: chemokine activity
Biological process: immune response
Cellular component: extracellular region

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00048
Domain description: Small cytokines (intecrine/chemokine), interleukin-8 like
Occurring in:
  1. Neutrophil-activating peptide 2
The deposited structure of PDB entry 1nap contains 4 copies of Pfam domain PF00048 (Small cytokines (intecrine/chemokine), interleukin-8 like) in Neutrophil-activating peptide 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001089
Domain description: CXC chemokine
Occurring in:
  1. Neutrophil-activating peptide 2
IPR001811
Domain description: Chemokine interleukin-8-like domain
Occurring in:
  1. Neutrophil-activating peptide 2
IPR018048
Domain description: CXC chemokine, conserved site
Occurring in:
  1. Neutrophil-activating peptide 2
IPR036048
Domain description: Chemokine interleukin-8-like superfamily
Occurring in:
  1. Neutrophil-activating peptide 2
IPR033899
Domain description: CXC Chemokine domain
Occurring in:
  1. Neutrophil-activating peptide 2

Structure domain

CATH CATH domain
2.40.50.40
Class: Mainly Beta
Architecture: Beta Barrel
Topology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Occurring in:
  1. Neutrophil-activating peptide 2
The deposited structure of PDB entry 1nap contains 4 copies of CATH domain 2.40.50.40 (OB fold (Dihydrolipoamide Acetyltransferase, E2P)) in Neutrophil-activating peptide 2. Showing 1 copy in chain A.
SCOP SCOP annotation
54118
Class: Alpha and beta proteins (a+b)
Fold: IL8-like
Superfamily: Interleukin 8-like chemokines
Occurring in:
  1. Neutrophil-activating peptide 2
The deposited structure of PDB entry 1nap contains 4 copies of SCOP domain 54118 (Interleukin 8-like chemokines) in Neutrophil-activating peptide 2. Showing 1 copy in chain A.

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