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Crystal structure of E. coli MTA/AdoHcy nucleosidase complexed with formycin A (FMA)

Source organism: Escherichia coli
Biochemical function: protein homodimerization activity
Biological process: toxic metabolite repair
Cellular component: cytosol

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EC 3.2.2.9: Adenosylhomocysteine nucleosidase

Reaction catalysed:
5'-deoxyadenosine + H(2)O = 5-deoxy-D-ribose + adenine
Systematic name:
S-adenosyl-L-homocysteine homocysteinylribohydrolase
Alternative Name(s):
  • 5'-methyladenosine nucleosidase
  • AdoHcy/MTA nucleosidase
  • S-adenosylhomocysteine hydrolase
  • S-adenosylhomocysteine nucleosidase
  • S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01048
Domain description: Phosphorylase superfamily
Occurring in:
  1. 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
The deposited structure of PDB entry 1nc3 contains 2 copies of Pfam domain PF01048 (Phosphorylase superfamily) in 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR035994
Domain description: Nucleoside phosphorylase superfamily
Occurring in:
  1. 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
IPR010049
Domain description: MTA/SAH nucleosidase
Occurring in:
  1. 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
IPR000845
Domain description: Nucleoside phosphorylase domain
Occurring in:
  1. 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

Structure domain

CATH CATH domain
3.40.50.1580
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Nucleoside phosphorylase domain
Occurring in:
  1. 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
The deposited structure of PDB entry 1nc3 contains 2 copies of CATH domain 3.40.50.1580 (Rossmann fold) in 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. Showing 1 copy in chain A.
SCOP SCOP annotation
53168
Class: Alpha and beta proteins (a/b)
Fold: Phosphorylase/hydrolase-like
Superfamily: Purine and uridine phosphorylases
Occurring in:
  1. 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
The deposited structure of PDB entry 1nc3 contains 2 copies of SCOP domain 53168 (Purine and uridine phosphorylases) in 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. Showing 1 copy in chain A.

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