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Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with Ribavirin Monophosphate and C2-Mycophenolic Adenine Dinucleotide

Source organism: Homo sapiens
Biochemical function: metal ion binding
Biological process: 'de novo' XMP biosynthetic process
Cellular component: ficolin-1-rich granule lumen

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EC 1.1.1.205: IMP dehydrogenase

Reaction catalysed:
Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH
Systematic name:
IMP:NAD(+) oxidoreductase
Alternative Name(s):
  • IMP oxidoreductase
  • Inosinate dehydrogenase
  • Inosine 5'-monophosphate dehydrogenase
  • Inosine monophosphate dehydrogenase
  • Inosine monophosphate oxidoreductase
  • Inosine-5'-phosphate dehydrogenase
  • Inosinic acid dehydrogenase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00571
Domain description: CBS domain
Occurring in:
  1. Inosine-5'-monophosphate dehydrogenase 2
The deposited structure of PDB entry 1nf7 contains 4 copies of Pfam domain PF00571 (CBS domain) in Inosine-5'-monophosphate dehydrogenase 2. Showing 2 copies in chain A.

PF00478
Domain description: IMP dehydrogenase / GMP reductase domain
Occurring in:
  1. Inosine-5'-monophosphate dehydrogenase 2
The deposited structure of PDB entry 1nf7 contains 2 copies of Pfam domain PF00478 (IMP dehydrogenase / GMP reductase domain) in Inosine-5'-monophosphate dehydrogenase 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000644
Domain description: CBS domain
Occurring in:
  1. Inosine-5'-monophosphate dehydrogenase 2
IPR005990
Domain description: Inosine-5'-monophosphate dehydrogenase
Occurring in:
  1. Inosine-5'-monophosphate dehydrogenase 2
IPR001093
Domain description: IMP dehydrogenase/GMP reductase
Occurring in:
  1. Inosine-5'-monophosphate dehydrogenase 2
IPR015875
Domain description: IMP dehydrogenase / GMP reductase, conserved site
Occurring in:
  1. Inosine-5'-monophosphate dehydrogenase 2
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. Inosine-5'-monophosphate dehydrogenase 2

Structure domain

CATH CATH domain
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. Inosine-5'-monophosphate dehydrogenase 2
The deposited structure of PDB entry 1nf7 contains 2 copies of CATH domain 3.20.20.70 (TIM Barrel) in Inosine-5'-monophosphate dehydrogenase 2. Showing 1 copy in chain A.
SCOP SCOP annotations
51413
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: Inosine monophosphate dehydrogenase (IMPDH)
Occurring in:
  1. Inosine-5'-monophosphate dehydrogenase 2
The deposited structure of PDB entry 1nf7 contains 2 copies of SCOP domain 51413 (Inosine monophosphate dehydrogenase (IMPDH)) in Inosine-5'-monophosphate dehydrogenase 2. Showing 1 copy in chain A.
54632
Class: Alpha and beta proteins (a+b)
Fold: CBS-domain pair
Superfamily: CBS-domain pair
Occurring in:
  1. Inosine-5'-monophosphate dehydrogenase 2
The deposited structure of PDB entry 1nf7 contains 2 copies of SCOP domain 54632 (CBS-domain pair) in Inosine-5'-monophosphate dehydrogenase 2. Showing 1 copy in chain A.

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