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I-KAPPA-B-ALPHA/NF-KAPPA-B COMPLEX

Source organism: Homo sapiens
Biochemical function: DNA-binding transcription factor activity
Biological process: regulation of DNA-templated transcription
Cellular component: cytoplasm

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00023
Domain description: Ankyrin repeat
Occurring in:
  1. NF-kappa-B inhibitor alpha
The deposited structure of PDB entry 1nfi contains 8 copies of Pfam domain PF00023 (Ankyrin repeat) in NF-kappa-B inhibitor alpha. Showing 4 copies in chain E.

PF16179
Domain description: Rel homology dimerisation domain
Occurring in:
  1. Transcription factor p65
  2. Nuclear factor NF-kappa-B p50 subunit
The deposited structure of PDB entry 1nfi contains 2 copies of Pfam domain PF16179 (Rel homology dimerisation domain) in Transcription factor p65. Showing 1 copy in chain C.
The deposited structure of PDB entry 1nfi contains 2 copies of Pfam domain PF16179 (Rel homology dimerisation domain) in Nuclear factor NF-kappa-B p50 subunit. Showing 1 copy in chain B.

PF00554
Domain description: Rel homology DNA-binding domain
Occurring in:
  1. Transcription factor p65
The deposited structure of PDB entry 1nfi contains 2 copies of Pfam domain PF00554 (Rel homology DNA-binding domain) in Transcription factor p65. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR002110
Domain description: Ankyrin repeat
Occurring in:
  1. NF-kappa-B inhibitor alpha
IPR000451
Domain description: NF-kappa-B/Dorsal
Occurring in:
  1. Transcription factor p65
  2. Nuclear factor NF-kappa-B p50 subunit
IPR036770
Domain description: Ankyrin repeat-containing domain superfamily
Occurring in:
  1. NF-kappa-B inhibitor alpha
IPR032397
Domain description: Rel homology dimerisation domain
Occurring in:
  1. Transcription factor p65
  2. Nuclear factor NF-kappa-B p50 subunit
IPR033926
Domain description: NFkappaB IPT domain
Occurring in:
  1. Transcription factor p65
  2. Nuclear factor NF-kappa-B p50 subunit
IPR002909
Domain description: IPT domain
Occurring in:
  1. Transcription factor p65
  2. Nuclear factor NF-kappa-B p50 subunit
IPR014756
Domain description: Immunoglobulin E-set
Occurring in:
  1. Transcription factor p65
  2. Nuclear factor NF-kappa-B p50 subunit
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Transcription factor p65
  2. Nuclear factor NF-kappa-B p50 subunit
IPR011539
Domain description: Rel homology domain, DNA-binding domain
Occurring in:
  1. Transcription factor p65
IPR030492
Domain description: Rel homology domain, conserved site
Occurring in:
  1. Transcription factor p65
IPR037059
Domain description: Rel homology domain (RHD), DNA-binding domain superfamily
Occurring in:
  1. Transcription factor p65
IPR030495
Domain description: Transcription factor p65, RHD domain, N-terminal
Occurring in:
  1. Transcription factor p65
IPR008967
Domain description: p53-like transcription factor, DNA-binding domain superfamily
Occurring in:
  1. Transcription factor p65

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Transcription factor p65
  2. Nuclear factor NF-kappa-B p50 subunit
The deposited structure of PDB entry 1nfi contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Transcription factor p65. Showing 1 copy in chain C.
The deposited structure of PDB entry 1nfi contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Nuclear factor NF-kappa-B p50 subunit. Showing 1 copy in chain B.
1.25.40.20
Class: Mainly Alpha
Architecture: Alpha Horseshoe
Topology: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homology: Ankyrin repeat-containing domain
Occurring in:
  1. NF-kappa-B inhibitor alpha
The deposited structure of PDB entry 1nfi contains 2 copies of CATH domain 1.25.40.20 (Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat) in NF-kappa-B inhibitor alpha. Showing 1 copy in chain E.
2.60.40.340
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Rel homology domain (RHD), DNA-binding domain
Occurring in:
  1. Transcription factor p65
The deposited structure of PDB entry 1nfi contains 2 copies of CATH domain 2.60.40.340 (Immunoglobulin-like) in Transcription factor p65. Showing 1 copy in chain C.
SCOP SCOP annotations
81279
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: E set domains
Occurring in:
  1. Transcription factor p65
  2. Nuclear factor NF-kappa-B p50 subunit
The deposited structure of PDB entry 1nfi contains 2 copies of SCOP domain 81279 (NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain) in Transcription factor p65. Showing 1 copy in chain C.
The deposited structure of PDB entry 1nfi contains 2 copies of SCOP domain 81279 (NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain) in Nuclear factor NF-kappa-B p50 subunit. Showing 1 copy in chain B.
48404
Class: Alpha and beta proteins (a+b)
Fold: beta-hairpin-alpha-hairpin repeat
Superfamily: Ankyrin repeat
Occurring in:
  1. NF-kappa-B inhibitor alpha
The deposited structure of PDB entry 1nfi contains 2 copies of SCOP domain 48404 (Ankyrin repeat) in NF-kappa-B inhibitor alpha. Showing 1 copy in chain E.
81315
Class: All beta proteins
Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
Superfamily: p53-like transcription factors
Occurring in:
  1. Transcription factor p65
The deposited structure of PDB entry 1nfi contains 2 copies of SCOP domain 81315 (Rel/Dorsal transcription factors, DNA-binding domain) in Transcription factor p65. Showing 1 copy in chain C.

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