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Rv2002 gene product from Mycobacterium tuberculosis

Source organism: Mycobacterium tuberculosis
Biochemical function: androstan-3-alpha,17-beta-diol dehydrogenase activity
Biological process: steroid metabolic process
Cellular component: plasma membrane

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EC 1.1.1.53: 3-alpha(or 20-beta)-hydroxysteroid dehydrogenase

Reaction catalysed:
Androstan-3-alpha,17-beta-diol + NAD(+) = 17-beta-hydroxyandrostan-3-one + NADH
Systematic name:
3-alpha(or 20-beta)-hydroxysteroid:NAD(+) oxidoreductase
Alternative Name(s):
  • (R)-20-hydroxysteroid dehydrogenase
  • 20-beta-HSD
  • 20-beta-hydroxysteroid dehydrogenase
  • 3-alpha,20-beta-hydroxysteroid:NAD(+)-oxidoreductase
  • Cortisone reductase
  • Dehydrogenase, 20-beta-hydroxy steroid
  • Delta(4)-3-ketosteroid hydrogenase
  • NADH-20-beta-hydroxysteroid dehydrogenase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF13561
Domain description: Enoyl-(Acyl carrier protein) reductase
Occurring in:
  1. 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase
The deposited structure of PDB entry 1nfq contains 4 copies of Pfam domain PF13561 (Enoyl-(Acyl carrier protein) reductase) in 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002347
Domain description: Short-chain dehydrogenase/reductase SDR
Occurring in:
  1. 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase
IPR020904
Domain description: Short-chain dehydrogenase/reductase, conserved site
Occurring in:
  1. 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase

Structure domain

CATH CATH domain
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase
The deposited structure of PDB entry 1nfq contains 4 copies of CATH domain 3.40.50.720 (Rossmann fold) in 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase. Showing 1 copy in chain A.
SCOP SCOP annotation
51751
Class: Alpha and beta proteins (a/b)
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Occurring in:
  1. 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase
The deposited structure of PDB entry 1nfq contains 4 copies of SCOP domain 51751 (Tyrosine-dependent oxidoreductases) in 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase. Showing 1 copy in chain A.

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