› 1nix

Solution NMR

THREE DIMENSIONAL SOLUTION STRUCTURE OF HAINANTOXIN-I BY 2D 1H-NMR

Released:
DOI: 10.2210/pdb1nix/pdb
PDB entry 1nix coloured by chain, ensemble of 20 models, front view.
PDB entry 1nix coloured by chain, ensemble of 20 models, side view.
PDB entry 1nix coloured by chain, ensemble of 20 models, top view.
Source organism: Haplopelma hainanum
Primary publication:
Function and solution structure of hainantoxin-I, a novel insect sodium channel inhibitor from the Chinese bird spider Selenocosmia hainana.
Li D, Xiao Y, Hu W, Xie J, Bosmans F, Tytgat J, Liang S
FEBS Lett 555 616-22 (2003)
PMID: 14675784

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112433 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mu-theraphotoxin-Hhn2b 1 Chain: A
Molecule details ›
Chain: A
Length: 34 amino acids
Theoretical weight: 3.62 KDa
Source organism: Haplopelma hainanum
UniProt:
  • Canonical: D2Y1X6 (Residues: 49-81; Coverage: 53%)
Sequence domains: Ion channel inhibitory toxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing

Quick links

Citations

16 review citations

Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads.
Klint et al. (2012)
15 more

3 mentions without citation

Unique scorpion toxin with a putative ancestral fold provides insight into evolution of the inhibitor cystine knot motif.
Smith et al. (2011)
2 more