› 1nq0

X-ray diffraction
2.4Å resolution

TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit Decreased Stability in the Nterminal LBD

Released:
DOI: 10.2210/pdb1nq0/pdb
PDB entry 1nq0 coloured by chain, front view.
PDB entry 1nq0 coloured by chain, side view.
PDB entry 1nq0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain.
Huber BR, Desclozeaux M, West BL, Cunha-Lima ST, Nguyen HT, Baxter JD, Ingraham HA, Fletterick RJ
Mol Endocrinol 17 107-16 (2003)
PMID: 12511610

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-145480 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thyroid hormone receptor beta Chain: A
Molecule details ›
Chain: A
Length: 263 amino acids
Theoretical weight: 29.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10828 (Residues: 202-461; Coverage: 56%)
Gene names: ERBA2, NR1A2, THR1, THRB
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand 4HY 1 x 4HY
Ligand ARS 6 x ARS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P3121
Unit cell:
a: 68.82Å b: 68.82Å c: 131.07Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.218 0.218 0.258
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Thyroid hormone receptor mutations and disease: beyond thyroid hormone resistance.
Cheng SY. (2005)
2 more

3 mentions without citation

Directory of useful decoys, enhanced (DUD-E): better ligands and decoys for better benchmarking.
Mysinger et al. (2012)
2 more