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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78791.

X-ray diffraction
1.9Å resolution
PDB entry 1o4p coloured by chain, front view.
PDB entry 1o4p coloured by chain, side view.
PDB entry 1o4p coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Proto-oncogene tyrosine-protein kinase Src
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Multimeric state: monomeric
Accessible surface area: 6313.08 Å2
Buried surface area: 379.33 Å2
Dissociation area: 189.66 Å2
Dissociation energy (ΔGdiss): 0.92 kcal/mol
Dissociation entropy (TΔSdiss): 2.68 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-146379

Macromolecules

Proto-oncogene tyrosine-protein kinase Src
Chain: A
Length: 108 amino acids
Theoretical weight: 12.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P12931 (Residues: 145-252; Coverage: 20%)
Gene names: SRC, SRC1
Pfam: SH2 domain
InterPro:
CATH: SH2 domain
SCOP: SH2 domain
Proto-oncogene tyrosine-protein kinase Src in PDB entry 1o4p, assembly 1, front view.
Proto-oncogene tyrosine-protein kinase Src in PDB entry 1o4p, assembly 1, side view.
Proto-oncogene tyrosine-protein kinase Src in PDB entry 1o4p, assembly 1, top view.
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