› 1o7s

X-ray diffraction
1.75Å resolution

High resolution structure of Siglec-7

Released:
DOI: 10.2210/pdb1o7s/pdb
PDB entry 1o7s coloured by chain, front view.
PDB entry 1o7s coloured by chain, side view.
PDB entry 1o7s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family.
Alphey MS, Attrill H, Crocker PR, van Aalten DM
J Biol Chem 278 3372-7 (2003)
PMID: 12438315

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195116 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sialic acid-binding Ig-like lectin 7 Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 14.66 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q9Y286 (Residues: 18-144; Coverage: 28%)
Gene names: AIRM1, SIGLEC7
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:
Ligand CYS 1 x CYS
Ligand NAG 1 x NAG
Ligand NDG 1 x NDG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P41212
Unit cell:
a: 53.078Å b: 53.078Å c: 93.77Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.221 0.248
Expression system: Cricetulus griseus

Quick links

Citations

19 review citations

Siglecs and their roles in the immune system.
Crocker et al. (2007)
18 more

6 mentions without citation

Current Status on Therapeutic Molecules Targeting Siglec Receptors.
Lenza et al. (2020)
5 more