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D405N mutant of the CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS in complex with methyl-tetrathio-alpha-d-cellopentoside at 1.1 angstrom resolution

Source organism: Humicola insolens
Biochemical function: hydrolase activity, hydrolyzing O-glycosyl compounds
Biological process: cellulose catabolic process
Cellular component: not assigned

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EC 3.2.1.91: Cellulose 1,4-beta-cellobiosidase (non-reducing end)

Reaction catalysed:
Hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains
Systematic name:
4-beta-D-glucan cellobiohydrolase (non-reducing end)
Alternative Name(s):
  • 1,4-beta-cellobiohydrolase
  • 1,4-beta-glucan cellobiosidase
  • Avicelase
  • Beta-1,4-glucan cellobiohydrolase
  • Beta-1,4-glucan cellobiosylhydrolase
  • C1 cellulase
  • CBH 1
  • Cellobiohydrolase
  • Cellobiohydrolase I
  • Cellobiosidase
  • Exo-1,4-beta-D-glucanase
  • Exo-beta-1,4-glucan cellobiohydrolase
  • Exo-cellobiohydrolase
  • Exocellobiohydrolase
  • Exoglucanase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF01341
Domain description: Glycosyl hydrolases family 6
Occurring in:
  1. Exoglucanase-6A
The deposited structure of PDB entry 1oc7 contains 1 copy of Pfam domain PF01341 (Glycosyl hydrolases family 6) in Exoglucanase-6A. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR016288
Domain description: 1, 4-beta cellobiohydrolase
Occurring in:
  1. Exoglucanase-6A
IPR001524
Domain description: Glycoside hydrolase, family 6, conserved site
Occurring in:
  1. Exoglucanase-6A
IPR036434
Domain description: 1, 4-beta cellobiohydrolase superfamily
Occurring in:
  1. Exoglucanase-6A

Structure domain

CATH CATH domain
3.20.20.40
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: 1, 4-beta cellobiohydrolase
Occurring in:
  1. Exoglucanase-6A
The deposited structure of PDB entry 1oc7 contains 1 copy of CATH domain 3.20.20.40 (TIM Barrel) in Exoglucanase-6A. Showing 1 copy in chain A.
SCOP SCOP annotation
51990
Class: Alpha and beta proteins (a/b)
Fold: 7-stranded beta/alpha barrel
Superfamily: Glycosyl hydrolases family 6, cellulases
Occurring in:
  1. Exoglucanase-6A
The deposited structure of PDB entry 1oc7 contains 1 copy of SCOP domain 51990 (Glycosyl hydrolases family 6, cellulases) in Exoglucanase-6A. Showing 1 copy in chain A.

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