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X-ray diffraction
2.19Å resolution

THE CRYSTAL STRUCTURE OF HUMAN S100A12 - COPPER COMPLEX

Released:
DOI: 10.2210/pdb1odb/pdb
PDB entry 1odb coloured by chain, front view.
PDB entry 1odb coloured by chain, side view.
PDB entry 1odb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the human S100A12-copper complex: implications for host-parasite defence.
Moroz OV, Antson AA, Grist SJ, Maitland NJ, Dodson GG, Wilson KS, Lukanidin E, Bronstein IB
Acta Crystallogr D Biol Crystallogr 59 859-67 (2003)
PMID: 12777802

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160420 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein S100-A12 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 95 amino acids
Theoretical weight: 10.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P80511 (Residues: 2-92; Coverage: 99%)
Gene name: S100A12
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand

Ligands and Environments

2 bound ligands:
Ligand CU 6 x CU
Ligand CA 12 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P21212
Unit cell:
a: 70.569Å b: 118.957Å c: 90.185Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.226
Expression system: Escherichia coli

Quick links

Citations

25 review citations

Functions of S100 proteins.
Donato et al. (2013)
24 more

10 mentions without citation

Manganese and microbial pathogenesis: sequestration by the Mammalian immune system and utilization by microorganisms.
Brophy et al. (2015)
9 more