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STRUCTURAL BASIS FOR BILE ACID BINDING AND ACTIVATION OF THE NUCLEAR RECEPTOR FXR

Source organisms:
Biochemical function: bile acid binding
Biological process: bile acid signaling pathway
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00104
Domain description: Ligand-binding domain of nuclear hormone receptor
Occurring in:
  1. Bile acid receptor
The deposited structure of PDB entry 1osv contains 2 copies of Pfam domain PF00104 (Ligand-binding domain of nuclear hormone receptor) in Bile acid receptor. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001723
Domain description: Nuclear hormone receptor
Occurring in:
  1. Bile acid receptor
IPR001728
Domain description: Thyroid hormone receptor
Occurring in:
  1. Bile acid receptor
IPR000536
Domain description: Nuclear hormone receptor, ligand-binding domain
Occurring in:
  1. Bile acid receptor
IPR035500
Domain description: Nuclear hormone receptor-like domain superfamily
Occurring in:
  1. Bile acid receptor
IPR044114
Domain description: Bile acid receptor, ligand binding domain
Occurring in:
  1. Bile acid receptor

Structure domain

CATH CATH domain
1.10.565.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Retinoid X Receptor
Homology: Retinoid X Receptor
Occurring in:
  1. Bile acid receptor
The deposited structure of PDB entry 1osv contains 2 copies of CATH domain 1.10.565.10 (Retinoid X Receptor) in Bile acid receptor. Showing 1 copy in chain A.
SCOP SCOP annotation
48509
Class: All alpha proteins
Fold: Nuclear receptor ligand-binding domain
Superfamily: Nuclear receptor ligand-binding domain
Occurring in:
  1. Bile acid receptor
The deposited structure of PDB entry 1osv contains 2 copies of SCOP domain 48509 (Nuclear receptor ligand-binding domain) in Bile acid receptor. Showing 1 copy in chain A.

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