Function and Biology

Crystal structure of a complex formed between organic solvent treated bovine alpha-chymotrypsin and its autocatalytically produced highly potent 14-residue peptide at 2.2 resolution

Source organism: Bos taurus
Biochemical function: serpin family protein binding
Biological process: digestion
Cellular component: serine protease inhibitor complex

EC 3.4.21.1: Chymotrypsin

Reaction catalysed:
Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.
Systematic name:
-
Alternative Name(s):
  • Alpha-chymar
  • Alpha-chymar ophth
  • Alpha-chymotrypsin
  • Alpha-chymotrypsin A
  • Avazyme
  • Chymar
  • Chymotest
  • Chymotrypsin A
  • Chymotrypsin B
  • Chymotrypsins A and B
  • Enzeon
  • Quimar
  • Quimotrase

Sequence family

Pfam Protein family (Pfam)
PF00089
Domain description: Trypsin
Occurring in:
  1. Chymotrypsinogen A
The deposited structure of PDB entry 1oxg contains 1 copy of Pfam domain PF00089 (Trypsin) in Chymotrypsinogen A. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Chymotrypsinogen A
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Chymotrypsinogen A
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Chymotrypsinogen A
IPR033116
Domain description: Serine proteases, trypsin family, serine active site
Occurring in:
  1. Chymotrypsinogen A
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Chymotrypsinogen A
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Chymotrypsinogen A

Structure domain

CATH CATH domain
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Chymotrypsinogen A
The deposited structure of PDB entry 1oxg contains 2 copies of CATH domain 2.40.10.10 (Thrombin, subunit H) in Chymotrypsinogen A. Showing 2 copies in chain A.
SCOP SCOP annotation
50514
Class: All beta proteins
Fold: Trypsin-like serine proteases
Superfamily: Trypsin-like serine proteases
Occurring in:
  1. Chymotrypsinogen A
The deposited structure of PDB entry 1oxg contains 1 copy of SCOP domain 50514 (Eukaryotic proteases) in Chymotrypsinogen A. Showing 1 copy in chain A.