› 1oxp

X-ray diffraction
2.5Å resolution

ASPARTATE AMINOTRANSFERASE, H-ASP COMPLEX, CLOSED CONFORMATION

Released:
DOI: 10.2210/pdb1oxp/pdb
PDB entry 1oxp coloured by chain, front view.
PDB entry 1oxp coloured by chain, side view.
PDB entry 1oxp coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Crystal structures and solution studies of oxime adducts of mitochondrial aspartate aminotransferase.
Marković-Housley Z, Schirmer T, Hohenester E, Khomutov AR, Khomutov RM, Karpeisky MY, Sandmeier E, Christen P, Jansonius JN
Eur J Biochem 236 1025-32 (1996)
PMID: 8665890

Function and Biology Details

Reactions catalysed: 
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate
(1a) L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132574 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aspartate aminotransferase, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 401 amino acids
Theoretical weight: 44.99 KDa
Source organism: Gallus gallus
Expression system: unidentified
UniProt:
  • Canonical: P00508 (Residues: 23-423; Coverage: 95%)
Gene name: GOT2
Sequence domains: Aminotransferase class I and II
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand IK2 1 x IK2
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2221
Unit cell:
a: 69.5Å b: 91.55Å c: 128.36Å
α: 90° β: 90° γ: 90°
Expression system: unidentified

Quick links

Citations

1 review citation

Cystathionine-β-Synthase: Molecular Regulation and Pharmacological Inhibition.
Zuhra et al. (2020)
16 other articles

2 mentions without citation

High resolution crystal structures of human kynurenine aminotransferase-I bound to PLP cofactor, and in complex with aminooxyacetate.
Nadvi et al. (2017)
1 more