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Crystal Structure of Blood Coagulation Factor Xa in Complex with Ecotin M84R

Source organisms:
Biochemical function: calcium ion binding
Biological process: proteolysis
Cellular component: extracellular region

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EC 3.4.21.6: Coagulation factor Xa

Reaction catalysed:
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
Systematic name:
-
Alternative Name(s):
  • Activated Stuart-Prower factor
  • Activated blood-coagulation factor X
  • Activated factor X
  • Autoprothrombin C
  • Factor Xa
  • Plasma thromboplastin
  • Prothrombase
  • Prothrombinase
  • Stuart factor
  • Thrombokinase
  • Thromboplastin

GO terms

Sequence families

Pfam Protein families (Pfam)
PF14670
Domain description: Coagulation Factor Xa inhibitory site
Occurring in:
  1. Factor X light chain
The deposited structure of PDB entry 1p0s contains 1 copy of Pfam domain PF14670 (Coagulation Factor Xa inhibitory site) in Factor X light chain. Showing 1 copy in chain A [auth L].

PF00008
Domain description: EGF-like domain
Occurring in:
  1. Factor X light chain
The deposited structure of PDB entry 1p0s contains 1 copy of Pfam domain PF00008 (EGF-like domain) in Factor X light chain. Showing 1 copy in chain A [auth L] (this domain is out of the observed residue ranges!).

PF00594
Domain description: Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
Occurring in:
  1. Factor X light chain
The deposited structure of PDB entry 1p0s contains 1 copy of Pfam domain PF00594 (Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain) in Factor X light chain. Showing 1 copy in chain A [auth L].

PF00089
Domain description: Trypsin
Occurring in:
  1. Activated factor Xa heavy chain
The deposited structure of PDB entry 1p0s contains 1 copy of Pfam domain PF00089 (Trypsin) in Activated factor Xa heavy chain. Showing 1 copy in chain B [auth H].

PF03974
Domain description: Ecotin
Occurring in:
  1. Ecotin
The deposited structure of PDB entry 1p0s contains 1 copy of Pfam domain PF03974 (Ecotin) in Ecotin. Showing 1 copy in chain C [auth E].

InterPro InterPro annotations
IPR000294
Domain description: Gamma-carboxyglutamic acid-rich (GLA) domain
Occurring in:
  1. Factor X light chain
IPR000742
Domain description: EGF-like domain
Occurring in:
  1. Factor X light chain
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Activated factor Xa heavy chain
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Activated factor Xa heavy chain
IPR005658
Domain description: Proteinase inhibitor I11, ecotin
Occurring in:
  1. Ecotin
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Activated factor Xa heavy chain
IPR023084
Domain description: Proteinase inhibitor I11, ecotin, gammaproteobacteria
Occurring in:
  1. Ecotin
IPR000152
Domain description: EGF-type aspartate/asparagine hydroxylation site
Occurring in:
  1. Factor X light chain
IPR018097
Domain description: EGF-like calcium-binding, conserved site
Occurring in:
  1. Factor X light chain
IPR001881
Domain description: EGF-like calcium-binding domain
Occurring in:
  1. Factor X light chain
IPR035972
Domain description: Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
Occurring in:
  1. Factor X light chain
IPR017857
Domain description: Coagulation factor-like, Gla domain superfamily
Occurring in:
  1. Factor X light chain
IPR033116
Domain description: Serine proteases, trypsin family, serine active site
Occurring in:
  1. Activated factor Xa heavy chain
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Activated factor Xa heavy chain
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Activated factor Xa heavy chain
IPR027438
Domain description: Ecotin, C-terminal
Occurring in:
  1. Ecotin
IPR036198
Domain description: Ecotin superfamily
Occurring in:
  1. Ecotin

Structure domains

CATH CATH domains
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Activated factor Xa heavy chain
The deposited structure of PDB entry 1p0s contains 2 copies of CATH domain 2.40.10.10 (Thrombin, subunit H) in Activated factor Xa heavy chain. Showing 2 copies in chain B [auth H].
2.10.25.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Laminin
Homology: Laminin
Occurring in:
  1. Factor X light chain
The deposited structure of PDB entry 1p0s contains 1 copy of CATH domain 2.10.25.10 (Laminin) in Factor X light chain. Showing 1 copy in chain A [auth L].
4.10.740.10
Class: Few Secondary Structures
Architecture: Irregular
Topology: Coagulation Factor IX
Homology: Coagulation Factor IX
Occurring in:
  1. Factor X light chain
The deposited structure of PDB entry 1p0s contains 1 copy of CATH domain 4.10.740.10 (Coagulation Factor IX) in Factor X light chain. Showing 1 copy in chain A [auth L].
2.60.40.550
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Ecotin
Occurring in:
  1. Ecotin
The deposited structure of PDB entry 1p0s contains 1 copy of CATH domain 2.60.40.550 (Immunoglobulin-like) in Ecotin. Showing 1 copy in chain C [auth E].
SCOP SCOP annotations
57197
Class: Small proteins
Fold: Knottins (small inhibitors, toxins, lectins)
Superfamily: EGF/Laminin
Occurring in:
  1. Factor X light chain
The deposited structure of PDB entry 1p0s contains 1 copy of SCOP domain 57197 (EGF-type module) in Factor X light chain. Showing 1 copy in chain A [auth L].
57631
Class: Small proteins
Fold: GLA-domain
Superfamily: GLA-domain
Occurring in:
  1. Factor X light chain
The deposited structure of PDB entry 1p0s contains 1 copy of SCOP domain 57631 (GLA-domain) in Factor X light chain. Showing 1 copy in chain A [auth L].
50514
Class: All beta proteins
Fold: Trypsin-like serine proteases
Superfamily: Trypsin-like serine proteases
Occurring in:
  1. Activated factor Xa heavy chain
The deposited structure of PDB entry 1p0s contains 1 copy of SCOP domain 50514 (Eukaryotic proteases) in Activated factor Xa heavy chain. Showing 1 copy in chain B [auth H].
49773
Class: All beta proteins
Fold: Ecotin, trypsin inhibitor
Superfamily: Ecotin, trypsin inhibitor
Occurring in:
  1. Ecotin
The deposited structure of PDB entry 1p0s contains 1 copy of SCOP domain 49773 (Ecotin, trypsin inhibitor) in Ecotin. Showing 1 copy in chain C [auth E].

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