Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Fibronectin type III
- Interleukin-6/GCSF/MGF
- Fibronectin type III superfamily
- Immunoglobulin-like fold
- Four-helical cytokine-like, core
- Type I cytokine receptor, cytokine-binding domain
- Long hematopoietin receptor, soluble alpha chain, conserved site
- Interleukin-6/GCSF/MGF, conserved site
2 more domains
Structure domains:
Structure analysis Details
Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138620 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Interleukin-6 receptor subunit beta
Molecule details ›
Chain: A
Length: 299 amino acids
Theoretical weight: 34.1 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Structure domains: Immunoglobulins
Length: 299 amino acids
Theoretical weight: 34.1 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
P40189 (Residues: 23-321; Coverage: 33%)
Sequence domains:
Structure domains: Immunoglobulins
Interleukin-6
Molecule details ›
Chain: B
Length: 186 amino acids
Theoretical weight: 21.1 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Interleukin-6/G-CSF/MGF family
Structure domains: Growth Hormone; Chain: A;
Length: 186 amino acids
Theoretical weight: 21.1 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: P05231 (Residues: 29-212; Coverage: 100%)
Sequence domains: Interleukin-6/G-CSF/MGF family
Structure domains: Growth Hormone; Chain: A;
Soluble interleukin-6 receptor subunit alpha
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
wwPDB Validation report is not available for this entry.
X-ray source:
ALS BEAMLINE 8.2.1
Spacegroup:
R32
Expression system: Spodoptera frugiperda
