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Solution structure of human mitochondria fission protein Fis1

Source organism: Homo sapiens
Biochemical function: molecular adaptor activity
Biological process: positive regulation of intrinsic apoptotic signaling pathway
Cellular component: protein-containing complex

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF14853
Domain description: Fis1 C-terminal tetratricopeptide repeat
Occurring in:
  1. Mitochondrial fission 1 protein
The deposited structure of PDB entry 1pc2 contains 1 copy of Pfam domain PF14853 (Fis1 C-terminal tetratricopeptide repeat) in Mitochondrial fission 1 protein. Showing 1 copy in chain A.

PF14852
Domain description: Fis1 N-terminal tetratricopeptide repeat
Occurring in:
  1. Mitochondrial fission 1 protein
The deposited structure of PDB entry 1pc2 contains 1 copy of Pfam domain PF14852 (Fis1 N-terminal tetratricopeptide repeat) in Mitochondrial fission 1 protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR016543
Domain description: Mitochondria fission 1 protein
Occurring in:
  1. Mitochondrial fission 1 protein
IPR011990
Domain description: Tetratricopeptide-like helical domain superfamily
Occurring in:
  1. Mitochondrial fission 1 protein
IPR028061
Domain description: Fis1, C-terminal tetratricopeptide repeat
Occurring in:
  1. Mitochondrial fission 1 protein
IPR028058
Domain description: Fis1, N-terminal tetratricopeptide repeat
Occurring in:
  1. Mitochondrial fission 1 protein
IPR033745
Domain description: Mitochondria fission protein Fis1, cytosolic domain
Occurring in:
  1. Mitochondrial fission 1 protein

Structure domain

CATH CATH domain
1.25.40.10
Class: Mainly Alpha
Architecture: Alpha Horseshoe
Topology: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homology: Tetratricopeptide repeat domain
Occurring in:
  1. Mitochondrial fission 1 protein
The deposited structure of PDB entry 1pc2 contains 1 copy of CATH domain 1.25.40.10 (Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat) in Mitochondrial fission 1 protein. Showing 1 copy in chain A.
SCOP SCOP annotation
48453
Class: All alpha proteins
Fold: alpha-alpha superhelix
Superfamily: TPR-like
Occurring in:
  1. Mitochondrial fission 1 protein
The deposited structure of PDB entry 1pc2 contains 1 copy of SCOP domain 48453 (Tetratricopeptide repeat (TPR)) in Mitochondrial fission 1 protein. Showing 1 copy in chain A.

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