› › Function and Biology

Crystal structure of groEL-groES

Source organism: Escherichia coli
Biochemical function: unfolded protein binding
Biological process: chaperone cofactor-dependent protein refolding
Cellular component: GroEL-GroES complex

Quick links

EC 5.6.1.7: Chaperonin ATPase

Reaction catalysed:
ATP + H(2)O + a folded polypeptide = ADP + phosphate + an unfolded polypeptide
Systematic name:
ATP phosphohydrolase (polypeptide-unfolding)
Alternative Name(s):
  • Chaperonin

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00118
Domain description: TCP-1/cpn60 chaperonin family
Occurring in:
  1. Chaperonin GroEL
The deposited structure of PDB entry 1pcq contains 14 copies of Pfam domain PF00118 (TCP-1/cpn60 chaperonin family) in Chaperonin GroEL. Showing 1 copy in chain A.

PF00166
Domain description: Chaperonin 10 Kd subunit
Occurring in:
  1. Co-chaperonin GroES
The deposited structure of PDB entry 1pcq contains 7 copies of Pfam domain PF00166 (Chaperonin 10 Kd subunit) in Co-chaperonin GroES. Showing 1 copy in chain O.

InterPro InterPro annotations
IPR001844
Domain description: Chaperonin Cpn60/GroEL
Occurring in:
  1. Chaperonin GroEL
IPR020818
Domain description: GroES chaperonin family
Occurring in:
  1. Co-chaperonin GroES
IPR027409
Domain description: GroEL-like apical domain superfamily
Occurring in:
  1. Chaperonin GroEL
IPR027410
Domain description: TCP-1-like chaperonin intermediate domain superfamily
Occurring in:
  1. Chaperonin GroEL
IPR027413
Domain description: GroEL-like equatorial domain superfamily
Occurring in:
  1. Chaperonin GroEL
IPR018370
Domain description: Chaperonin Cpn60, conserved site
Occurring in:
  1. Chaperonin GroEL
IPR002423
Domain description: Chaperonin Cpn60/GroEL/TCP-1 family
Occurring in:
  1. Chaperonin GroEL
IPR018369
Domain description: Chaperonin GroES, conserved site
Occurring in:
  1. Co-chaperonin GroES
IPR037124
Domain description: GroES chaperonin superfamily
Occurring in:
  1. Co-chaperonin GroES
IPR011032
Domain description: GroES-like superfamily
Occurring in:
  1. Co-chaperonin GroES

Structure domains

CATH CATH domains
3.30.260.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: GROEL; domain 2
Homology: TCP-1-like chaperonin intermediate domain
Occurring in:
  1. Chaperonin GroEL
The deposited structure of PDB entry 1pcq contains 14 copies of CATH domain 3.30.260.10 (GROEL; domain 2) in Chaperonin GroEL. Showing 1 copy in chain A.
1.10.560.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: GROEL; domain 1
Homology: GroEL-like equatorial domain
Occurring in:
  1. Chaperonin GroEL
The deposited structure of PDB entry 1pcq contains 14 copies of CATH domain 1.10.560.10 (GROEL; domain 1) in Chaperonin GroEL. Showing 1 copy in chain A.
3.50.7.10
Class: Alpha Beta
Architecture: 3-Layer(bba) Sandwich
Topology: GroEL
Homology: GroEL
Occurring in:
  1. Chaperonin GroEL
The deposited structure of PDB entry 1pcq contains 14 copies of CATH domain 3.50.7.10 (GroEL) in Chaperonin GroEL. Showing 1 copy in chain A.
2.30.33.40
Class: Mainly Beta
Architecture: Roll
Topology: 10 Kd Chaperonin, Protein Cpn10; Chain O
Homology: GroES chaperonin
Occurring in:
  1. Co-chaperonin GroES
The deposited structure of PDB entry 1pcq contains 7 copies of CATH domain 2.30.33.40 (10 Kd Chaperonin, Protein Cpn10; Chain O) in Co-chaperonin GroES. Showing 1 copy in chain O.
SCOP SCOP annotations
54850
Class: Alpha and beta proteins (a+b)
Fold: GroEL-intermediate domain like
Superfamily: GroEL-intermediate domain like
Occurring in:
  1. Chaperonin GroEL
The deposited structure of PDB entry 1pcq contains 14 copies of SCOP domain 54850 (GroEL-like chaperone, intermediate domain) in Chaperonin GroEL. Showing 1 copy in chain A.
48593
Class: All alpha proteins
Fold: GroEL equatorial domain-like
Superfamily: GroEL equatorial domain-like
Occurring in:
  1. Chaperonin GroEL
The deposited structure of PDB entry 1pcq contains 14 copies of SCOP domain 48593 (GroEL chaperone, ATPase domain) in Chaperonin GroEL. Showing 1 copy in chain A.
52030
Class: Alpha and beta proteins (a/b)
Fold: The "swivelling" beta/beta/alpha domain
Superfamily: GroEL apical domain-like
Occurring in:
  1. Chaperonin GroEL
The deposited structure of PDB entry 1pcq contains 14 copies of SCOP domain 52030 (GroEL-like chaperone, apical domain) in Chaperonin GroEL. Showing 1 copy in chain A.
50130
Class: All beta proteins
Fold: GroES-like
Superfamily: GroES-like
Occurring in:
  1. Co-chaperonin GroES
The deposited structure of PDB entry 1pcq contains 7 copies of SCOP domain 50130 (GroES) in Co-chaperonin GroES. Showing 1 copy in chain O.

Quick links