Function and Biology

PF4-M2 CHIMERIC MUTANT WITH THE FIRST 10 N-TERMINAL RESIDUES OF R-PF4 REPLACED BY THE N-TERMINAL RESIDUES OF THE IL8 SEQUENCE. MODELS 1-15 OF A 27-MODEL SET.

Sequence family

Pfam Protein family (Pfam)
PF00048
Domain description: Small cytokines (intecrine/chemokine), interleukin-8 like
Occurring in:
  1. Platelet factor 4
The deposited structure of PDB entry 1pfm contains 4 copies of Pfam domain PF00048 (Small cytokines (intecrine/chemokine), interleukin-8 like) in Platelet factor 4. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001089
Domain description: CXC chemokine
Occurring in:
  1. Platelet factor 4
IPR001811
Domain description: Chemokine interleukin-8-like domain
Occurring in:
  1. Platelet factor 4
IPR018048
Domain description: CXC chemokine, conserved site
Occurring in:
  1. Platelet factor 4
IPR033899
Domain description: CXC Chemokine domain
Occurring in:
  1. Platelet factor 4
IPR036048
Domain description: Chemokine interleukin-8-like superfamily
Occurring in:
  1. Platelet factor 4

Structure domain

CATH CATH domain
2.40.50.40
Class: Mainly Beta
Architecture: Beta Barrel
Topology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Occurring in:
  1. Platelet factor 4
The deposited structure of PDB entry 1pfm contains 4 copies of CATH domain 2.40.50.40 (OB fold (Dihydrolipoamide Acetyltransferase, E2P)) in Platelet factor 4. Showing 1 copy in chain A.
SCOP SCOP annotation
54118
Class: Alpha and beta proteins (a+b)
Fold: IL8-like
Superfamily: Interleukin 8-like chemokines
Occurring in:
  1. Platelet factor 4
The deposited structure of PDB entry 1pfm contains 4 copies of SCOP domain 54118 (Interleukin 8-like chemokines) in Platelet factor 4. Showing 1 copy in chain A.